CPSF7

CPSF7
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3N9U
Identifikatori
Aliasi	CPSF7
Vanjski ID-jevi	MGI: 1917826 HomoloGene: 11731 GeneCards: CPSF7
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	61,430,031 bp
Lokacija gena (miš)
Hrom.	Hromosom 19 (miš)
Kraj	10,525,017 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • vezivanje sa RNK;
Ćelijska komponenta	• membrana; • jedro; • nukleoplazma; • mRNA cleavage factor complex; • citoplazma; • mRNA cleavage and polyadenylation specificity factor complex;
Biološki proces	• mRNA splicing, via spliceosome; • termination of RNA polymerase II transcription; • mRNA processing; • mRNA 3'-end processing; • protein tetramerization; • protein heterotetramerization; • pre-mRNA cleavage required for polyadenylation; • mRNA alternative polyadenylation; • messenger ribonucleoprotein complex assembly;
	Izvori:Amigo / QuickGO
Ortolozi
	79869
	269061
	ENSG00000149532
	ENSMUSG00000034820
	Q8N684
	Q8BTV2
	NM_001136040; NM_001142565; NM_024811
	NM_001164272; NM_172302; NM_001362450
	NP_001129512; NP_001136037; NP_079087
	NP_001157744; NP_758506; NP_001349379
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica 7 faktora specifičnosti cijepanja i poliadenilacije je protein koji je kod ljudi kodiran genom CPSF7.^[5]^[6]

Aminokiselinska sekvenca

CPSF7, takođe poznat i kao CFIm59, je faktor cijepanja dva blisko povezana proteinska kompleksA u 3' netranslatiranoj regiji molekuli novosintetizirane pre-iRNK, koja se koristi u transkripciji gena.^[8] CPSF7 je jedan od tri faktora specifičnosti cijepanja i poliadenilacije (CPSF), a druga dva su CFIm25 (ili CPSF5/NUDT21) i CFIm68 (ili CPSF6).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149532 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034820 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (decembar 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".
^ "UniProt, Q8N684". Pristupljeno 20. 8. 2021.
^ Hardy JG, Norbury CJ (august 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID 27528751.

Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (maj 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (maj 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Rüegsegger U, Beyer K, Keller W (mart 1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". The Journal of Biological Chemistry. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.