STX11

STX11
Identifikatori
Aliasi	STX11
Vanjski ID-jevi	OMIM: 605014 MGI: 1921982 HomoloGene: 2792 GeneCards: STX11
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	144,191,939 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	12,840,042 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • SNARE binding; • SNAP receptor activity;
Ćelijska komponenta	• integral component of membrane; • ćelijska membrana; • Golđijev aparat; • SNARE complex; • membrana; • Sinapsna vezikula; • Endomembranski sistem; • presynaptic membrane; • presynaptic active zone membrane;
Biološki proces	• protein transport; • vesicle docking; • synaptic vesicle fusion to presynaptic active zone membrane; • membrane fusion; • vesicle-mediated transport; • intracellular protein transport; • Egzocitoza; • Fuzija vezikula;
	Izvori:Amigo / QuickGO
Ortolozi
	8676
	74732
	ENSG00000135604
	ENSMUSG00000039232
	O75558
	Q9D3G5
	NM_003764
	NM_001163590; NM_001163591; NM_029075
	NP_003755
	NP_001157062; NP_001157063; NP_083351
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sintaksin 11, znan i kao STX11, jest kod ljudski gen, član porodice t-SNARE.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 287 aminokiselina, a molekulska težina 33.196 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKDRLAELLD	LSKQYDQQFP	DGDDEFDSPH	EDIVFETDHI	LESLYRDIRD
IQDENQLLVA	DVKRLGKQNA	RFLTSMRRLS	SIKRDTNSIA	KAIKARGEVI
HCKLRAMKEL	SEAAEAQHGP	HSAVARISRA	QYNALTLTFQ	RAMHDYNQAE
MKQRDNCKIR	IQRQLEIMGK	EVSGDQIEDM	FEQGKWDVFS	ENLLADVKGA
RAALNEIESR	HRELLRLESR	IRDVHELFLQ	MAVLVEKQAD	TLNVIELNVQ
KTVDYTGQAK	AQVRKAVQYE	EKNPCRTLCC	FCCPCLK

Interakcije

Pokazalo se da STX11 reaguje sa SNAP25^[6]^[7] i SNAP23.^[6]^[8]

Također pogledajte

Hemofagocitna limfohistiocitoza

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135604 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039232 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: STX11 syntaxin 11".
^ ^a ^b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein–protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
^ Valdez AC, Cabaniols JP, Brown MJ, Roche PA (Mar 1999). "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network". Journal of Cell Science. 112 (6): 845–54. doi:10.1242/jcs.112.6.845. PMID 10036234.

Dopunska literatura

Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH (Apr 1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments". The Journal of Biological Chemistry. 273 (17): 10317–24. doi:10.1074/jbc.273.17.10317. PMID 9553086.
Tang BL, Low DY, Hong W (Apr 1998). "Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain". Biochemical and Biophysical Research Communications. 245 (2): 627–32. doi:10.1006/bbrc.1998.8490. PMID 9571206.
Valdez AC, Cabaniols JP, Brown MJ, Roche PA (Mar 1999). "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network". Journal of Cell Science. 112 (6): 845–54. doi:10.1242/jcs.112.6.845. PMID 10036234.
Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (Mar 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". Journal of Leukocyte Biology. 65 (3): 397–406. doi:10.1002/jlb.65.3.397. hdl:10261/59829. PMID 10080545. S2CID 18988377.
Roperch JP, Lethrone F, Prieur S, Piouffre L, Israeli D, Tuynder M, Nemani M, Pasturaud P, Gendron MC, Dausset J, Oren M, Amson RB, Telerman A (Jul 1999). "SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1)". Proceedings of the National Academy of Sciences of the United States of America. 96 (14): 8070–3. Bibcode:1999PNAS...96.8070R. doi:10.1073/pnas.96.14.8070. PMC 22189. PMID 10393949.
zur Stadt U, Schmidt S, Kasper B, Beutel K, Diler AS, Henter JI, Kabisch H, Schneppenheim R, Nürnberg P, Janka G, Hennies HC (Mar 2005). "Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11". Human Molecular Genetics. 14 (6): 827–34. doi:10.1093/hmg/ddi076. PMID 15703195.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein–protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Yamamoto K, Ishii E, Horiuchi H, Ueda I, Ohga S, Nishi M, Ogata Y, Zaitsu M, Morimoto A, Hara T, Imashuku S, Sasazuki T, Yasukawa M (2006). "Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people". Journal of Human Genetics. 50 (11): 600–3. doi:10.1007/s10038-005-0293-1. PMID 16180048.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Zur Stadt U, Beutel K, Kolberg S, Schneppenheim R, Kabisch H, Janka G, Hennies HC (Jan 2006). "Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A". Human Mutation. 27 (1): 62–8. doi:10.1002/humu.20274. PMID 16278825. S2CID 19226893.
Bryceson YT, Rudd E, Zheng C, Edner J, Ma D, Wood SM, Bechensteen AG, Boelens JJ, Celkan T, Farah RA, Hultenby K, Winiarski J, Roche PA, Nordenskjöld M, Henter JI, Long EO, Ljunggren HG (Sep 2007). "Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients". Blood. 110 (6): 1906–15. doi:10.1182/blood-2007-02-074468. PMC 1976360. PMID 17525286.
Arneson LN, Brickshawana A, Segovis CM, Schoon RA, Dick CJ, Leibson PJ (Sep 2007). "Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity". Journal of Immunology. 179 (6): 3397–401. doi:10.4049/jimmunol.179.6.3397. PMID 17785771.

Vanjski linkovi

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135604 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039232 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STX11 syntaxin 11".

[pmid16189514-6] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid16169070-7] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein–protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.

[pmid10036234-8] Valdez AC, Cabaniols JP, Brown MJ, Roche PA (Mar 1999). "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network". Journal of Cell Science. 112 (6): 845–54. doi:10.1242/jcs.112.6.845. PMID 10036234.

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