IK (gen)
Izgled
Protein Red jest protein koji je kod ljudi kodiran genom IK sa hromosoma 5.[5][6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 557 aminokiselina, а molekulska težina 65.602 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MPERDSEPFS | NPLAPDGHDV | DDPHSFHQSK | LTNEDFRKLL | MTPRAAPTSA | ||||
PPSKSRHHEM | PREYNEDEDP | AARRRKKKSY | YAKLRQQEIE | RERELAEKYR | ||||
DRAKERRDGV | NKDYEETELI | STTANYRAVG | PTAEADKSAA | EKRRQLIQES | ||||
KFLGGDMEHT | HLVKGLDFAL | LQKVRAEIAS | KEKEEEELME | KPQKETKKDE | ||||
DPENKIEFKT | RLGRNVYRML | FKSKAYERNE | LFLPGRMAYV | VDLDDEYADT | ||||
DIPTTLIRSK | ADCPTMEAQT | TLTTNDIVIS | KLTQILSYLR | QGTRNKKLKK | ||||
KDKGKLEEKK | PPEADMNIFE | DIGDYVPSTT | KTPRDKERER | YRERERDRER | ||||
DRDRDRERER | ERDRERERER | DREREEEKKR | HSYFEKPKVD | DEPMDVDKGP | ||||
GSTKELIKSI | NEKFAGSAGW | EGTESLKKPE | DKKQLGDFFG | MSNSYAECYP | ||||
ATMDDMAVDS | DEEVDYSKMD | QGNKKGPLGR | WDFDTQEEYS | EYMNNKEALP | ||||
KAAFQYGIKM | SEGRKTRRFK | ETNDKAELDR | QWKKISAIIE | KRKKMEADGV | ||||
EVKRPKY |
Funkcija
[uredi | uredi izvor]Protein kodiran ovim genom identificiran je njegovim RED ponavljanjem, nizom ponovljenih ostataka arginina, glutaminske kiseline i asparaginske kiseline. Protein se nalazi u diskretnim tačkicama unutar jedra, isključujući nukleolus. Njegova funkcija nije poznata. Ovaj gen se mapira na hromosomu 5; međutim, njegov pseudogen može biti i na hromosomu 2.[6]
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000113141 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024474 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Krief P, Augery-Bourget Y, Plaisance S, Merck MF, Assier E, Tanchou V, Billard M, Boucheix C, Jasmin C, Azzarone B (Dec 1994). "A new cytokine (IK) down-regulating HLA class II: monoclonal antibodies, cloning and chromosome localization". Oncogene. 9 (12): 3449–56. PMID 7970704.
- ^ a b "Entrez Gene: IK IK cytokine, down-regulator of HLA II".
- ^ "UniProt, Q13123" (jezik: engleski). Pristupljeno 16. 10. 2021.
Dopunska literatura
[uredi | uredi izvor]- Cao LX, Le Bousse-Kerdiles MC, Clay D, et al. (1997). "Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation". Blood. 89 (10): 3615–23. doi:10.1182/blood.V89.10.3615. PMID 9160666.
- Assier E, Bouzinba-Segard H, Stolzenberg MC, et al. (1999). "Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat". Gene. 230 (2): 145–54. doi:10.1016/S0378-1119(99)00066-9. PMID 10216252.
- Willers J, Häffner A, Zepter K, et al. (2001). "The interferon inhibiting cytokine IK is overexpressed in cutaneous T cell lymphoma derived tumor cells that fail to upregulate major histocompatibility complex class II upon interferon-gamma stimulation". J. Invest. Dermatol. 116 (6): 874–9. doi:10.1046/j.1523-1747.2001.01339.x. PMID 11407974.