Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes (Q93341322)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30481490%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

title

Intracellular metalloprotease activity controls intraneuronal Aβ aggregation and limits secretion of Aβ via exosomes (English)

1 reference

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5 May 2020

author name string

Javier Pacheco-Quinto

1 reference

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5 May 2020

Dana Clausen

1 reference

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5 May 2020

Rocío Pérez-González

1 reference

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5 May 2020

Hui Peng

1 reference

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5 May 2020

Austin Meszaros

1 reference

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5 May 2020

Christopher B Eckman

1 reference

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5 May 2020

Efrat Levy

1 reference

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5 May 2020

Elizabeth A Eckman

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5 May 2020

publication date

27 November 2018

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5 May 2020

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5 May 2020

volume

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5 May 2020

issue

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5 May 2020

page(s)

3758-3771

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describes a project that uses

5 May 2020

ImageQuant

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11 June 2022

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inferred from PubMed Central ID database lookup

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6404562/fullTextXML

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11 February 2021

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11 February 2021

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Trafficking and proteolytic processing of APP

11 February 2021

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Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide

11 February 2021

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11 February 2021

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Neprilysin-2 is an important β-amyloid degrading enzyme

11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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11 February 2021

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Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review

11 February 2021

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11 February 2021

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11 February 2021

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Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme

11 February 2021

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11 February 2021

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Demonstration of a common artifact in immunosorbent assays of brain extracts: development of a solid-phase extraction protocol to enable measurement of amyloid-beta from wild-type rodent brain

11 February 2021

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Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

11 February 2021

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Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

11 February 2021

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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

11 February 2021

1 reference

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Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

11 February 2021

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

11 February 2021

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Intraneuronal Abeta42 accumulation in Down syndrome brain

11 February 2021

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Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

11 February 2021

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Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease

11 February 2021

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A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP).

11 February 2021

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Metabolic regulation of brain Abeta by neprilysin

11 February 2021

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Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

11 February 2021

1 reference

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Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

11 February 2021

1 reference

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Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6404562

Inhibitor potencies and substrate preference for endothelin-converting enzyme-1 are dramatically affected by pH

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6404562

A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6404562

Two di-leucine-based motifs account for the different subcellular localizations of the human endothelin-converting enzyme (ECE-1) isoforms

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6404562

Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6404562

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6404562

Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6404562

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

11 February 2021

1 reference

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Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs

11 February 2021

1 reference

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11 February 2021

Identifiers

DOI

10.1096/FJ.201801319R

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30481490%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30481490%20AND%20SRC:MED&resulttype=core&format=json

5 May 2020

PubMed publication ID

30481490

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30481490%20AND%20SRC:MED&resulttype=core&format=json