Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire (Q92670526)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30920391%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

title

Crossreactive public TCR sequences undergo positive selection in the human thymic repertoire (English)

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1 May 2020

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1 May 2020

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1 May 2020

author name string

Mohsen Khosravi-Maharlooei

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1 May 2020

Aditya Misra

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1 May 2020

Keshav Motwani

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1 May 2020

Markus Holzl

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1 May 2020

Susan DeWolf

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1 May 2020

Grace Nauman

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1 May 2020

Nichole Danzl

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1 May 2020

Haowei Li

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1 May 2020

Siu-Hong Ho

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1 May 2020

Robert Winchester

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1 May 2020

Yufeng Shen

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1 May 2020

Todd M Brusko

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1 May 2020

Megan Sykes

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1 May 2020

publication date

28 March 2019

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Journal of Clinical Investigation

1 May 2020

published in

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1 May 2020

volume

129

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1 May 2020

issue

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1 May 2020

page(s)

2446-2462

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30920391%20AND%20SRC:MED&resulttype=core&format=json

Quantifying size and diversity of the human T cell alloresponse

1 May 2020

cites work

1 reference

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T Cell Receptor Profiling in Type 1 Diabetes

11 February 2021

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Learning the High-Dimensional Immunogenomic Features That Predict Public and Private Antibody Repertoires.

11 February 2021

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Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity

11 February 2021

1 reference

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Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes.

11 February 2021

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Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes

11 February 2021

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Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

11 February 2021

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A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) α and β repertoires and identifying potential new invariant TCR α chains

11 February 2021

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Genetic variation in MHC proteins is associated with T cell receptor expression biases

11 February 2021

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T cell receptor diversity in the human thymus.

11 February 2021

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Hydrophobic CDR3 residues promote the development of self-reactive T cells

11 February 2021

1 reference

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Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination

11 February 2021

1 reference

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Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells

11 February 2021

1 reference

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Ikaros, Helios, and Aiolos protein levels increase in human thymocytes after β selection

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

High diversity in the TCR repertoire of GAD65 autoantigen-specific human CD4+ T cells

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Diversity and clonal selection in the human T-cell repertoire

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Molecules in medicine mini review: the αβ T cell receptor

11 February 2021

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Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Cross-reactivity of T cells and its role in the immune system

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Why must T cells be cross-reactive?

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

A model for personalized in vivo analysis of human immune responsiveness

11 February 2021

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Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

11 February 2021

1 reference

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Half of the T-cell repertoire combinatorial diversity is genetically determined in humans and humanized mice.

11 February 2021

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A single autoimmune T cell receptor recognizes more than a million different peptides

11 February 2021

1 reference

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T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

11 February 2021

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Shortening of complementarity determining region 3 of the T cell receptor α chain during thymocyte development.

11 February 2021

1 reference

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Shaping the T-cell repertoire in the periphery

11 February 2021

1 reference

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Shaping the T‐cell repertoire: a matter of life and death

11 February 2021

1 reference

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Overlap and Effective Size of the Human CD8 + T Cell Receptor Repertoire

11 February 2021

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T cell receptor CDR3 loops influence alphabeta pairing

11 February 2021

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High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets

11 February 2021

1 reference

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Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

High diversity of the immune repertoire in humanized NOD.SCID.gamma c-/- mice

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Comparison of CDR3 length among thymocyte subpopulations: impacts of MHC and BV segment on the CDR3 shortening.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Development of TCRB CDR3 length repertoire of human T lymphocytes

11 February 2021

1 reference

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T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires

11 February 2021

1 reference

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CDR3 loop flexibility contributes to the degeneracy of TCR recognition

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Most alpha/beta T cell receptor diversity is due to terminal deoxynucleotidyl transferase

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Thymocyte maturation: selection for in-frame TCR alpha-chain rearrangement is followed by selection for shorter TCR beta-chain complementarity-determining region 3.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

A direct estimate of the human alphabeta T cell receptor diversity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Membrane protein folding and stability: physical principles

11 February 2021

1 reference

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Skewed TCRV beta repertoire in human thymus persists after thymic emigration: influence of genomic imposition, thymic maturation and environmental challenge on human TCRV beta usage in vivo.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Genetic control of T cell receptor BJ gene expression in peripheral lymphocytes of normal and rheumatoid arthritis monozygotic twins

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Differential usage of T cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins

11 February 2021

1 reference

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The expressed T cell receptor V gene repertoire of rheumatoid arthritis monozygotic twins: rapid analysis by anchored polymerase chain reaction and enzyme-linked immunosorbent assay.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Sequence analysis of the human alpha beta T-cell receptor CDR3 region

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Expression of terminal deoxynucleotidyl transferase in human thymus during ontogeny and development

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

A special repertoire of alpha:beta T cells in neonatal mice

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

Variability in T cell receptor V beta gene usage in human peripheral blood lymphocytes. Studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6546456

11 February 2021

Identifiers

DOI

10.1172/JCI124358

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30920391%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30920391%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PubMed publication ID

30920391

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30920391%20AND%20SRC:MED&resulttype=core&format=json