Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers (Q91861212)

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scientific article published on 10 December 2019

Language	Label	Description	Also known as
English	Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers	scientific article published on 10 December 2019

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scholarly article

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31823525%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31823525%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

pharmacodynamics

1 reference

based on heuristic

inferred from title

pharmacokinetics

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based on heuristic

inferred from title

9

object named as

Bryan Laffitte

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31823525%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

author name string

Michael K Badman

1

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25 April 2020

Jin Chen

2

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25 April 2020

Sachin Desai

3

1 reference

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25 April 2020

Soniya Vaidya

4

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25 April 2020

Srikanth Neelakantham

5

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25 April 2020

Jie Zhang

6

1 reference

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25 April 2020

Lu Gan

7

1 reference

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25 April 2020

Kate Danis

8

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25 April 2020

Lloyd B Klickstein

10

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25 April 2020

publication date

10 December 2019

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25 April 2020

Clinical pharmacology in drug development

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Europe PubMed Central

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25 April 2020

9

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25 April 2020

3

1 reference

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25 April 2020

395-410

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31823525%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

Identification of a nuclear receptor for bile acids

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Bile acids: natural ligands for an orphan nuclear receptor

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Roles of FGF19 in liver metabolism.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

The farnesoid X-receptor is an essential regulator of cholesterol homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Incomplete response to ursodeoxycholic acid in primary biliary cirrhosis: is a double dosage worthwhile?

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Obesity and nonalcoholic fatty liver disease: current perspectives

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

FXR induces SOCS3 and suppresses hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

The Farnesoid X Receptor: Good for BAD.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of obeticholic acid on lipoprotein metabolism in healthy volunteers.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

The TGR5 receptor mediates bile acid-induced itch and analgesia

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.

1 reference

https://api.crossref.org/works/10.1002%2FCPDD.762

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CPDD.762

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31823525%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31823525%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

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