The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo (Q91651000)

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23 April 2020

title

The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo (English)

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23 April 2020

1 reference

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23 April 2020

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23 April 2020

Sarah Weber

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23 April 2020

Sebastian E Koschade

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23 April 2020

Christopher M Hoffmann

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23 April 2020

Taronish D Dubash

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23 April 2020

Klara M Giessler

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23 April 2020

Friederike Herbst

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23 April 2020

Hanno Glimm

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23 April 2020

publication date

3 December 2019

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23 April 2020

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23 April 2020

volume

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23 April 2020

issue

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23 April 2020

page(s)

1181

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Liquid biopsy for rectal cancer: A systematic review

23 April 2020

cites work

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Molecular Characterization of Circulating Tumor Cells Enriched by A Microfluidic Platform in Patients with Small-Cell Lung Cancer

23 February 2021

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Clinical Potential of Circulating Tumor Cells in Colorectal Cancer: A Prospective Study

23 February 2021

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Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition and reduction of cancer stem cells and circulating tumor cells

23 February 2021

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PMN-MDSCs Enhance CTC Metastatic Properties through Reciprocal Interactions via ROS/Notch/Nodal Signaling

23 February 2021

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Engineering 3D approaches to model the dynamic microenvironments of cancer bone metastasis.

23 February 2021

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A Prognostic Model Based on Circulating Tumour Cells is Useful for Identifying the Poorest Survival Outcome in Patients with Metastatic Colorectal Cancer

23 February 2021

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The NOTCH4-HEY1 pathway induces epithelial mesenchymal transition in head and neck squamous cell carcinoma

23 February 2021

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3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments.

23 February 2021

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What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue

23 February 2021

1 reference

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Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells.

23 February 2021

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Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

23 February 2021

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Epigenetic inactivation of transforming growth factor-β1 target gene HEYL, a novel tumor suppressor, is involved in the P53-induced apoptotic pathway in hepatocellular carcinoma

23 February 2021

1 reference

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MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.

23 February 2021

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Cause of death from liver metastases in colorectal cancer

23 February 2021

1 reference

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Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients.

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Notch activation stimulates migration of breast cancer cells and promotes tumor growth

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Notch3 and HEY-1 as prognostic biomarkers in pancreatic adenocarcinoma.

23 February 2021

1 reference

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NCBI GEO: archive for functional genomics data sets--update

23 February 2021

1 reference

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Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Notch signaling pathway and cancer metastasis

23 February 2021

1 reference

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Notch: a key regulator of tumor angiogenesis and metastasis

23 February 2021

1 reference

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Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis

23 February 2021

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Tumor metastasis: molecular insights and evolving paradigms

23 February 2021

1 reference

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Distinct types of tumor-initiating cells form human colon cancer tumors and metastases

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors

23 February 2021

1 reference

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Hallmarks of Cancer: The Next Generation

23 February 2021

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Global signatures of protein and mRNA expression levels

23 February 2021

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Management of hepatic metastases from colorectal cancer

23 February 2021

1 reference

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Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

23 February 2021

1 reference

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Correlation of mRNA and protein in complex biological samples.

23 February 2021

1 reference

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HeyL regulates the number of TrkC neurons in dorsal root ganglia

23 February 2021

1 reference

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Experimental anti-tumor therapy in 3-D: spheroids--old hat or new challenge?

23 February 2021

1 reference

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Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function

23 February 2021

1 reference

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CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Identification and expansion of human colon-cancer-initiating cells

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Cancer metastasis: building a framework

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Tumor metastasis: mechanistic insights and clinical challenges

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Alterations in Vascular Gene Expression in Invasive Breast Carcinoma

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Endothelial cell diversity revealed by global expression profiling

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Hey genes in cardiovascular development

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

23 February 2021

The Hallmarks of Cancer

1 reference

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HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

A third-generation lentivirus vector with a conditional packaging system

23 February 2021

1 reference

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The distribution of secondary growths in cancer of the breast. 1889

23 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6892194

10.1186/S12885-019-6396-4

23 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31796022%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31796022%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

PubMed publication ID

31796022

1 reference

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