Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M-Positive Lung Cancer and Acquired Resistance to Osimertinib (Q90727978)

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scientific article published on 01 November 2018

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English	Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M-Positive Lung Cancer and Acquired Resistance to Osimertinib	scientific article published on 01 November 2018

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30073261%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

Assessment of Resistance Mechanisms and Clinical Implications in Patients With EGFR T790M-Positive Lung Cancer and Acquired Resistance to Osimertinib (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30073261%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

osimertinib mesylate

1 reference

ChEBI release 2020-05-28

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based on heuristic

inferred from title

2

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15 April 2020

author name string

Geoffrey R Oxnard

1

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15 April 2020

Kathryn F Mileham

3

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15 April 2020

Hatim Husain

4

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15 April 2020

Daniel B Costa

5

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15 April 2020

Philip Tracy

6

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15 April 2020

Nora Feeney

7

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15 April 2020

Lynette M Sholl

8

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15 April 2020

Suzanne E Dahlberg

9

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15 April 2020

Amanda J Redig

10

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15 April 2020

David J Kwiatkowski

11

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15 April 2020

Michael S Rabin

12

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15 April 2020

Cloud P Paweletz

13

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15 April 2020

Kenneth S Thress

14

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15 April 2020

Pasi A Jänne

15

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15 April 2020

language of work or name

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based on heuristic

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publication date

1 November 2018

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15 April 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30073261%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30073261%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

11

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15 April 2020

1527-1534

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30073261%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

BEAMing up for detection and quantification of rare sequence variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of acquired resistance to epidermal growth factor receptor kinase inhibitors in patients with advanced non-small cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delay of treatment change after objective progression on first-line erlotinib in epidermal growth factor receptor-mutant lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquired Resistance of EGFR-Mutant Lung Cancer to a T790M-Specific EGFR Inhibitor: Emergence of a Third Mutation (C797S) in the EGFR Tyrosine Kinase Domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGFR-independent mechanisms of acquired resistance to AZD9291 in EGFR T790M-positive NSCLC patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prospective Validation of Rapid Plasma Genotyping for the Detection of EGFR and KRAS Mutations in Advanced Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non-Small-Cell Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High MET amplification level as a resistance mechanism to osimertinib (AZD9291) in a patient that symptomatically responded to crizotinib treatment post-osimertinib progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Institutional implementation of clinical tumor profiling on an unselected cancer population

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acquired BRAF V600E Mutation as Resistant Mechanism after Treatment with Osimertinib.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osimertinib or Platinum-Pemetrexed in EGFR T790M-Positive Lung Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osimertinib benefit in EGFR-mutant NSCLC patients with T790M-mutation detected by circulating tumour DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting ALK: Precision Medicine Takes on Drug Resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osimertinib in Pretreated T790M-Positive Advanced Non-Small-Cell Lung Cancer: AURA Study Phase II Extension Component

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in TP53, PIK3CA, PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clonal History and Genetic Predictors of Transformation Into Small-Cell Carcinomas From Lung Adenocarcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osimertinib in Untreated EGFR-Mutated Advanced Non-Small-Cell Lung Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Impact of Smoking and TP53 mutations in lung adenocarcinoma patients with targetable mutations - the Lung Cancer Mutation Consortium (LCMC2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amplicon-based next-generation sequencing of plasma cell-free DNA for detection of driver and resistance mutations in advanced non-small cell lung cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30073261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1001/JAMAONCOL.2018.2969

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30073261%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30073261%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30073261%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

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