Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells (Q90727466)

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15 April 2020

title

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells (English)

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15 April 2020

Peng Wang

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Esra Karakose

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Hongtao Liu

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15 April 2020

Ethan Swartz

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Viktor Zlatanic

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Jessica Wilson

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Bryan J González

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Aaron Bender

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Karen K Takane

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Lillian Ye

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George Harb

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Dirk Homann

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Dieter Egli

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Carmen Argmann

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Donald K Scott

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Adolfo Garcia-Ocaña

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Andrew F Stewart

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publication date

20 December 2018

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volume

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issue

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page(s)

638-652.e5

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Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing.

15 April 2020

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Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

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Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human β-cell replication: a revised model of human β-cell G1/S control

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SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity.

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Combined modulation of polycomb and trithorax genes rejuvenates β cell replication

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12 December 2020

Diabetes mellitus--advances and challenges in human β-cell proliferation

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A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

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10.1016/J.CMET.2018.12.005

Identifiers

DOI

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15 April 2020

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15 April 2020

PubMed publication ID

30581122

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