Treg Fragility: A Prerequisite for Effective Antitumor Immunity? (Q90697940)

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15 April 2020

title

Treg Fragility: A Prerequisite for Effective Antitumor Immunity? (English)

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15 April 2020

author name string

Abigail E Overacre-Delgoffe

series ordinal

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15 April 2020

Dario A A Vignali

series ordinal

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15 April 2020

publication date

1 August 2018

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Cancer Immunology Research

15 April 2020

published in

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15 April 2020

volume

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15 April 2020

issue

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15 April 2020

page(s)

882-887

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Enhancement of antitumor immunity by CTLA-4 blockade

15 April 2020

cites work

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12 December 2020

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

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12 December 2020

Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

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Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

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12 December 2020

Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma

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12 December 2020

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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12 December 2020

Control of autoimmunity by naturally arising regulatory CD4+ T cells

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12 December 2020

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

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12 December 2020

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

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12 December 2020

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

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12 December 2020

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

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12 December 2020

Epigenetic control of the foxp3 locus in regulatory T cells

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12 December 2020

Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma

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12 December 2020

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

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12 December 2020

How regulatory T cells work

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12 December 2020

Dicer-dependent microRNA pathway safeguards regulatory T cell function

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12 December 2020

CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients

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12 December 2020

CTLA-4 control over Foxp3+ regulatory T cell function

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12 December 2020

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation

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12 December 2020

Plasticity of CD4(+) FoxP3(+) T cells

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12 December 2020

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

1 reference

12 December 2020

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

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12 December 2020

Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells

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12 December 2020

Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice

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12 December 2020

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

1 reference

12 December 2020

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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12 December 2020

Stability of the regulatory T cell lineage in vivo.

1 reference

12 December 2020

Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors

1 reference

12 December 2020

Foxo transcription factors control regulatory T cell development and function

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12 December 2020

In vivo Treg suppression assays

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12 December 2020

Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

1 reference

12 December 2020

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

1 reference

12 December 2020

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

1 reference

12 December 2020

Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study

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12 December 2020

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

1 reference

12 December 2020

The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences

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12 December 2020

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

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12 December 2020

T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development

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12 December 2020

Novel Foxo1-dependent transcriptional programs control T(reg) cell function

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12 December 2020

Regulatory T cells: recommendations to simplify the nomenclature.

1 reference

12 December 2020

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

1 reference

12 December 2020

Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.

1 reference

12 December 2020

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

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12 December 2020

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

1 reference

12 December 2020

GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability

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12 December 2020

Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans

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12 December 2020

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

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12 December 2020

E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.

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12 December 2020

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

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12 December 2020

T(reg) stability: to be or not to be.

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12 December 2020

Targeting regulatory T cells in tumors

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12 December 2020

Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity.

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12 December 2020

Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers

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12 December 2020

PD-1 marks dysfunctional regulatory T cells in malignant gliomas

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12 December 2020

Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity

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12 December 2020

Nutrients and the microenvironment to feed a T cell army

1 reference

12 December 2020

Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long Haul

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12 December 2020

Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity

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12 December 2020

Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity.

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12 December 2020

LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes.

1 reference

12 December 2020

10.1158/2326-6066.CIR-18-0066

Identifiers

DOI

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15 April 2020

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15 April 2020

PubMed publication ID

30068755

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30068755%20AND%20SRC:MED&resulttype=core&format=json