Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion (Q90087899)

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scientific article published on 06 September 2019

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English	Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion	scientific article published on 06 September 2019

Statements

instance of

scholarly article

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stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

title

Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion (English)

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stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

main subject

cell growth

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inferred from title

author

Brian S Cummings

series ordinal

6

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stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

author name string

Wided Najahi-Missaoui

series ordinal

1

1 reference

stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

Nhat D Quach

series ordinal

2

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stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

Amber Jenkins

series ordinal

3

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Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

Isha Dabke

series ordinal

4

1 reference

stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

Payaningal R Somanath

series ordinal

5

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stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

publication date

6 September 2019

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Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

published in

Pharmacology Research & Perspectives

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stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

volume

7

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Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

issue

5

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stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

page(s)

e00518

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Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

cites work

A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

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CD44 cell adhesion molecules

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

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P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

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PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

based on heuristic

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Wound-healing assay.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

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Spatiotemporal regulation of the Pak1 kinase

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bisphosphonate YM529 inhibits osteolytic and osteoblastic changes and CXCR-4-induced invasion in prostate cancer.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PAK1 hyperactivation is sufficient for mammary gland tumor formation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

based on heuristic

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Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pak protein kinases and their role in cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Knockdown of p21-activated kinase 6 inhibits prostate cancer growth and enhances chemosensitivity to docetaxel

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PAK1 as a therapeutic target

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretory phospholipase A 2 responsive liposomes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migration

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for distinct mechanisms of uptake and antitumor activity of secretory phospholipase A2 responsive liposome in prostate cancer.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical expression of MMP-9, TIMP-2, E-cadherin and vimentin in ameloblastomas and their implication in the local aggressive behavior of these tumors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance of adhesion molecules expression for estimation of serous ovarian cancer prognosis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of crosstalk between epithelial to mesenchymal transition molecules and MMP-9 mediates the antimetastatic activity of anethole in DU145 prostate cancer cells.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metastasis-associated protein 1 promotes tumor invasion by downregulation of E-cadherin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PAK signalling during the development and progression of cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of VCAM-1 and its associated molecule CD44 leads to increased malignant potential of breast cancer cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intricate role of CXCR4 in cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of p21-activated kinases (PAKs).

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomics analysis of E-cadherin knockdown in epithelial breast cancer cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanisms

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liposome-mediated delivery of the p21 activated kinase-1 (PAK-1) inhibitor IPA-3 limits prostate tumor growth in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cadherin-mediated cell-cell interactions in normal and cancer cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P21 activated kinase signaling in cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/31516713

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1002/PRP2.518

1 reference

stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

PMC publication ID

6728842

1 reference

stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

PubMed publication ID

31516713

1 reference

stated in

Europe PubMed Central

PMC publication ID

6728842

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31516713%20AND%20SRC:MED&resulttype=core&format=json

retrieved

11 April 2020

 

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