Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation (Q90068419)

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11 April 2020

title

Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation (English)

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11 April 2020

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11 April 2020

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11 April 2020

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11 April 2020

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11 April 2020

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11 April 2020

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11 April 2020

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11 April 2020

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11 April 2020

Brian A Aguado

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11 April 2020

Katherine B Schuetze

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11 April 2020

Carmen C Sucharov

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11 April 2020

Leslie A Leinwand

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11 April 2020

publication date

1 September 2019

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Science Translational Medicine

11 April 2020

published in

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11 April 2020

volume

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11 April 2020

issue

509

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Sex-dependent differences in left ventricular function and structure in chronic pressure overload

11 April 2020

cites work

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Deficiency of Interleukin-1 Receptor Antagonist Induces Aortic Valve Disease in BALB/c Mice

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Tumor Necrosis Factor-α Accelerates the Calcification of Human Aortic Valve Interstitial Cells Obtained from Patients with Calcific Aortic Valve Stenosis via the BMP2-Dlx5 Pathway

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Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts

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Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts.

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Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling.

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Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients

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Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus.

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Transcatheter aortic valve implantation 10-year anniversary: review of current evidence and clinical implications

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Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study

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12 December 2020

IL-1β suppresses TGF-β-mediated myofibroblast differentiation in cardiac fibroblasts.

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Fibrocalcific aortic valve disease: opportunity to understand disease mechanisms using mouse models

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12 December 2020

Transcatheter aortic valve implantation reduces sympathetic activity and normalizes arterial spontaneous baroreflex in patients with aortic stenosis

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12 December 2020

Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway

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12 December 2020

Aortic-valve stenosis--from patients at risk to severe valve obstruction

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12 December 2020

Cardiac valve cells and their microenvironment--insights from in vitro studies

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A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization

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12 December 2020

Integrating valve-inspired design features into poly(ethylene glycol) hydrogel scaffolds for heart valve tissue engineering.

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12 December 2020

Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment

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12 December 2020

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2-Year Outcomes in Patients Undergoing Surgical or Self-Expanding Transcatheter Aortic Valve Replacement

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Long-term Follow-up After Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis

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M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

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Drug Therapy for Heart Valve Diseases

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12 December 2020

Technical Approach Determines Inflammatory Response after Surgical and Transcatheter Aortic Valve Replacement

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12 December 2020

Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds.

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12 December 2020

Secretome identification of immune cell factors mediating metastatic cell homing.

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12 December 2020

Sex Differences in Aortic Stenosis and Outcome Following Surgical and Transcatheter Aortic Valve Replacement

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12 December 2020

Thromboinflammatory response and predictors of outcomes in patients undergoing transcatheter aortic valve replacement

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12 December 2020

Assessment of Prosthetic Valve Function After TAVR.

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12 December 2020

Sex-Specific Differences at Presentation and Outcomes Among Patients Undergoing Transcatheter Aortic Valve Replacement: A Cohort Study

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12 December 2020

Active tissue stiffness modulation controls valve interstitial cell phenotype and osteogenic potential in 3D culture

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12 December 2020

Simulation of early calcific aortic valve disease in a 3D platform: A role for myofibroblast differentiation.

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12 December 2020

The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

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12 December 2020

Transcatheter Aortic Valve Replacement 2016: A Modern-Day "Through the Looking-Glass" Adventure

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12 December 2020

Degenerative changes and immune response after transcatheter aortic valve implantation. Comparison with surgical aortic valve replacement.

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12 December 2020

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12 December 2020

Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis

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12 December 2020

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease

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Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

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TAVR Prognosis, Aging, and the Second TAVR Tsunami: Insights From France.

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Calcific Aortic Valve Disease: A Battle of the Sexes

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The shift of macrophages toward M1 phenotype promotes aortic valvular calcification

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Fibroblast-Specific Genetic Manipulation of p38 Mitogen-Activated Protein Kinase In Vivo Reveals Its Central Regulatory Role in Fibrosis

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12 December 2020

Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?

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Interferon-γ Released by Activated CD8+ T Lymphocytes Impairs the Calcium Resorption Potential of Osteoclasts in Calcified Human Aortic Valves.

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12 December 2020

Reversibility of Cardiac Function Predicts Outcome After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis

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Pathology of self-expanding transcatheter aortic valves: Findings from the CoreValve US pivotal trials

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12 December 2020

Engineering precision biomaterials for personalized medicine

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Biomaterial Scaffolds as Pre-metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment

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Spatiotemporal Multi-omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.

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Sex-Specific Outcomes After Transcatheter Aortic Valve Replacement: FDA Patient-Level Meta-Analysis of Premarket Clinical Trials

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A Reversible and Repeatable Thiol-Ene Bioconjugation for Dynamic Patterning of Signaling Proteins in Hydrogels

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Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement

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12 December 2020

10.1126/SCITRANSLMED.AAV3233

Identifiers

DOI

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11 April 2020

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11 April 2020

PubMed publication ID

31511425

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