Diosgenin Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial–Mesenchymal Transition by Down-regulation of Mdm2 and Vimentin (Q83903141)

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scientific article published on 02 May 2011

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English	Diosgenin Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial–Mesenchymal Transition by Down-regulation of Mdm2 and Vimentin	scientific article published on 02 May 2011

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Europe PubMed Central

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21504235

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29 January 2020

title

Diosgenin suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition by down-regulation of Mdm2 and vimentin (English)

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Europe PubMed Central

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21504235

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29 January 2020

Diosgenin Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial–Mesenchymal Transition by Down-regulation of Mdm2 and Vimentin (English)

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Crossref

DOI

10.1021/JF200598W

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30 November 2024

author

Earl Fu

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5

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Earl Fu

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Europe PubMed Central

PubMed publication ID

21504235

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author name string

Hsiang-Yu Chang

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1

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21504235

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29 January 2020

Ming-Ching Kao

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2

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21504235

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29 January 2020

Tzong-Der Way

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3

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21504235

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29 January 2020

Chi-Tang Ho

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4

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21504235

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language of work or name

English

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21504235

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publication date

2 May 2011

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21504235

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29 January 2020

full work available at URL

https://pubs.acs.org/doi/pdf/10.1021/jf200598w

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DOI

10.1021/JF200598W

reference URL

https://api.crossref.org/works/10.1021/JF200598W

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30 November 2024

published in

Journal of Agricultural and Food Chemistry

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Europe PubMed Central

PubMed publication ID

21504235

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21504235%20AND%20SRC:MED&resulttype=core&format=json

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29 January 2020

volume

59

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Europe PubMed Central

PubMed publication ID

21504235

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29 January 2020

issue

10

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PubMed publication ID

21504235

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29 January 2020

page(s)

5357-5363

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Europe PubMed Central

PubMed publication ID

21504235

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29 January 2020

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Epithelial-mesenchymal transitions in development and pathologies

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Crossref

DOI

10.1021/JF200598W

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30 November 2024

Epithelial-mesenchymal transitions in development and disease

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30 November 2024

Complex networks orchestrate epithelial-mesenchymal transitions

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EMT, the cytoskeleton, and cancer cell invasion

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The epithelial-mesenchymal transition generates cells with properties of stem cells

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

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p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

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Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells

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C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu

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Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells

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Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation

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Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor

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Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

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The green tea catechins, (-)-Epigallocatechin-3-gallate (EGCG) and (-)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells

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Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation

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Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin

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Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis

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Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation

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Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.

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Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth

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ERK and MMPs sequentially regulate distinct stages of epithelial tubule development

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Cancer Research

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31

volume

51

page(s)

4716

author name string

Isaacs W. B.

publication date

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10.1021/JF200598W

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Cancer Research

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63

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Gurova K. V.

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Epithelial-mesenchymal transitions in tumour progression

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Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front

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Vimentin is a novel AKT1 target mediating motility and invasion

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30 November 2024

Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

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The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

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The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations

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30 November 2024

Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells

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41

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10.1021/JF200598W

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30 November 2024

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DOI

10.1021/JF200598W

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21504235

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21504235%20AND%20SRC:MED&resulttype=core&format=json

retrieved

29 January 2020

PubMed publication ID

21504235

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21504235

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21504235%20AND%20SRC:MED&resulttype=core&format=json

retrieved

29 January 2020

 

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