Design of Antibody−Maytansinoid Conjugates Allows for Efficient Detoxification via Liver Metabolism (Q83579639)

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scientific article published on March 10, 2011

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English	Design of Antibody−Maytansinoid Conjugates Allows for Efficient Detoxification via Liver Metabolism	scientific article published on March 10, 2011

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instance of

scholarly article

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stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

title

Design of antibody-maytansinoid conjugates allows for efficient detoxification via liver metabolism (English)

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

Design of Antibody−Maytansinoid Conjugates Allows for Efficient Detoxification via Liver Metabolism (English)

1 reference

stated in

Crossref

DOI

10.1021/BC100498Q

reference URL

https://api.crossref.org/works/10.1021/BC100498Q

retrieved

26 November 2024

main subject

drug design

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21391620

retrieved

26 November 2024

author name string

Xiuxia Sun

series ordinal

1

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

Wayne Widdison

series ordinal

2

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

Michele Mayo

series ordinal

3

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

Sharon Wilhelm

series ordinal

4

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

Barbara Leece

series ordinal

5

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

Ravi Chari

series ordinal

6

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

Rajeeva Singh

series ordinal

7

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

Hans Erickson

series ordinal

8

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

language of work or name

English

1 reference

stated in

National Center for Biotechnology Information

PubMed publication ID

21391620

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21391620

retrieved

26 November 2024

publication date

10 March 2011

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

full work available at URL

https://pubs.acs.org/doi/pdf/10.1021/bc100498q

1 reference

stated in

Crossref

DOI

10.1021/BC100498Q

reference URL

https://api.crossref.org/works/10.1021/BC100498Q

retrieved

26 November 2024

published in

Bioconjugate Chemistry

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

volume

22

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

issue

4

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

page(s)

728-735

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

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Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer

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Superior antitumor activity of SAR3419 to rituximab in xenograft models for non-Hodgkin's lymphoma

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Alphav integrin-targeted immunoconjugates regress established human tumors in xenograft models

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The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo

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Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.

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Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen

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Cell killing by antibody-drug conjugates

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Identification of the sites of IgG catabolism in the rat

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10.1021/BC100498Q

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26 November 2024

In vivo trafficking and catabolism of IgG1 antibodies with Fc associated carbohydrates of differing structure

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A comparison of two murine monoclonal antibodies humanized by CDR-grafting and variable domain resurfacing

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Semisynthetic maytansine analogues for the targeted treatment of cancer

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Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates

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Drug Metabolism and Disposition

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page(s)

669

author name string

Keith R. A.

publication date

1985

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10.1021/BC100498Q

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26 November 2024

Metabolism of receptor targeted 111In-DTPA-glycoproteins: Identification of 111In-DTPA-ϵ-lysine as the primary metabolic and excretory product

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Contribution of linker stability to the activities of anticancer immunoconjugates

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The pharmacologic basis for antibody-auristatin conjugate activity

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In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates

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Antimicrotubular drugs binding to vinca domain of tubulin

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Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry

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Crossref

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10.1021/BC100498Q

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26 November 2024

Maytansine

series ordinal

28

1 reference

stated in

Crossref

DOI

10.1021/BC100498Q

reference URL

https://api.crossref.org/works/10.1021/BC100498Q

retrieved

26 November 2024

Identifiers

DOI

10.1021/BC100498Q

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

PubMed publication ID

21391620

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21391620

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21391620%20AND%20SRC:MED&resulttype=core&format=json

retrieved

25 January 2020

 

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