Pharmacological and behavioral characterization of the 5-HT2A receptor in C57BL/6N mice (Q83459516)

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scientific article published on February 22, 2011

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English	Pharmacological and behavioral characterization of the 5-HT2A receptor in C57BL/6N mice	scientific article published on February 22, 2011

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21340474

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Pharmacological and behavioral characterization of the 5-HT2A receptor in C57BL/6N mice (English)

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21340474

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John P. Dougherty

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1

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21340474

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Vincent J. Aloyo

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2

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21340474

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22 February 2011

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10.1007/S00213-011-2207-6

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Psychopharmacology

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21340474

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23 January 2020

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215

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21340474

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3

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21340474

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23 January 2020

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581-593

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23 January 2020

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5-HT2 receptor characteristics in frontal cortex and 5-HT2 receptor-mediated head-twitch behaviour following antidepressant treatment to mice

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Mutations of transmembrane IV and V serines indicate that all tryptamines do not bind to the rat 5-HT2A receptor in the same manner

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Intracerebroventricular administration of 5,7-dihydroxytryptamine to mice increases both head-twitch response and the number of cortical 5-HT2 receptors

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Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome

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Mechanism of tolerance development to 2,5-dimethoxy-4-iodoamphetamine in rats: down-regulation of the 5-HT2A, but not 5-HT2C, receptor.

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Rapid desensitization and down-regulation of 5-HT2 receptors by DOM treatment

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Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome

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Hallucinogenic drug interactions at human brain 5-HT2 receptors: implications for treating LSD-induced hallucinogenesis

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Guanyl nucleotide and divalent cation regulation of cortical S2 serotonin receptors

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12 December 2020

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Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites

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Site-directed mutagenesis of a single residue changes the binding properties of the serotonin 5-HT2 receptor from a human to a rat pharmacology

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Serotonin and Hallucinogens

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[3H]MDL 100,907: a novel selective 5-HT2A receptor ligand

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12 December 2020

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Behavioural and biochemical evidence that glucocorticoids are not involved in DOI-elicited 5-HT2 receptor down-regulation

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Serotonin receptor sensitivity after acute and chronic treatment with mianserin.

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5-HT2 receptors, roles and regulation

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Serotonin receptors in human neuroblastoma: a possible biologic tumor marker

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12 December 2020

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Molecular pharmacological differences in the interaction of serotonin with 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors

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12 December 2020

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Repeated DOI and SR 46349B treatments do not affect elevated plus-maze anxiety despite opposite effects on cortical 5-HT2A receptors

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Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors

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Role of serotonin and dopamine receptor binding in antipsychotic efficacy

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Characterization and regional distribution of serotonin S2-receptors in human brain

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12 December 2020

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Activity of Parthenolide at 5HT2A Receptors

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Differential binding of ergot compounds to human versus rat 5-HT2 cortical receptors

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Repeated administration of SR 46349B, a selective 5-hydroxytryptamine2 antagonist, up-regulates 5-hydroxytryptamine2 receptors in mouse brain.

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Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter

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Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist

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Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior

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In mice repeated administration of electroconvulsive shock or desmethylimipramine produces rapid alterations in 5-HT2-mediated head-twitch responses and cortical 5-HT2 receptor number

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The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease

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Serotonin receptors in the human brain--IV. Autoradiographic mapping of serotonin-2 receptors

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Regulation of 5-HT(2A) receptor mRNA levels and binding sites in rat frontal cortex by the agonist DOI and the antagonist mianserin

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Role of the serotonin 5-HT(2A) receptor in learning

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Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: evidence for species differences

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Physiological and therapeutic relevance of constitutive activity of 5-HT 2A and 5-HT 2C receptors for the treatment of depression

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of 5-HT2 receptors in the rat brain by repeated administration of SR 46349B, a selective 5-HT2 receptor antagonist

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: evidence for species differences in brain serotonin-2 receptors

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors

1 reference

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https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of chronic m-CPP on locomotion, hypophagia, plasma corticosterone and 5-HT2C receptor levels in the rat

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors

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12 December 2020

based on heuristic

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Transcriptome Fingerprints Distinguish Hallucinogenic and Nonhallucinogenic 5-Hydroxytryptamine 2A Receptor Agonist Effects in Mouse Somatosensory Cortex

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12 December 2020

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inferred from PubMed ID database lookup

Species differences in the pharmacology of the 5-hydroxytryptamine2 receptor: structurally specific differentiation by ergolines and tryptamines

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12 December 2020

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pH-dependent modulation of agonist interactions with [3H]-ketanserin-labelled S2 serotonin receptors

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-HT2A and 5-HT2C receptors and their atypical regulation properties

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective and divergent regulation of cortical 5-HT(2A) receptors in rabbit

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

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Serotonin 5- HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptors

1 reference

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12 December 2020

based on heuristic

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A genetic screen for mouse mutations with defects in serotonin responsiveness

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Withdrawal from chronic treatment with (+/-)-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology and distribution of human 5‐hydroxytryptamine2B (5‐HT2b) receptor gene products: comparison with 5‐HT2a and 5‐HT2c receptors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic action of 5-HT2A antagonists and selective serotonin reuptake inhibitors in neuropsychiatric disorders

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct central serotonin receptors with different physiological functions

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The time-course for up- and down-regulation of the cortical 5-hydroxytryptamine (5-HT)2A receptor density predicts 5-HT2A receptor-mediated behavior in the rabbit

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder

1 reference

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PubMed

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of nonserotonergic [3H]ketanserin binding sites associated with nerve terminals in rat brain and with platelets; relation with release of biogenic amine metabolites induced by ketanserin- and tetrabenazine-like drugs.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonist binding at 5-HT(2A) and 5-HT(2C) receptors in the rabbit: high correlation with the profile for the human receptors

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Similarities in the pharmacology of spontaneous and DOI-induced head-shakes suggest 5HT2A receptors are active under physiological conditions

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3H-DOB (4-bromo-2,5-dimethoxyphenylisopropylamine) labels a guanyl nucleotide-sensitive state of cortical 5-HT2 receptors

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis

1 reference

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https://pubmed.ncbi.nlm.nih.gov/21340474

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12 December 2020

based on heuristic

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Molecular Pharmacology

series ordinal

35

volume

45

page(s)

277

author name string

MP Johnson

publication date

1994

1 reference

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Crossref

DOI

10.1007/S00213-011-2207-6

reference URL

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25 November 2024

Molecular Pharmacology

series ordinal

39

volume

42

page(s)

328

author name string

S Leonhardt

publication date

1992

1 reference

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DOI

10.1007/S00213-011-2207-6

reference URL

https://api.crossref.org/works/10.1007/S00213-011-2207-6

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25 November 2024

Molecular Pharmacology

series ordinal

41

volume

21

page(s)

301

author name string

JE Leysen

publication date

1982

1 reference

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DOI

10.1007/S00213-011-2207-6

reference URL

https://api.crossref.org/works/10.1007/S00213-011-2207-6

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25 November 2024

Serotonin 2C receptor knockout mice: Autoradiographic analysis of multiple serotonin receptors

series ordinal

45

1 reference

stated in

Crossref

DOI

10.1007/S00213-011-2207-6

reference URL

https://api.crossref.org/works/10.1007/S00213-011-2207-6

retrieved

25 November 2024

Molecular Pharmacology

series ordinal

46

volume

31

page(s)

194

author name string

RA Lyon

publication date

1987

1 reference

stated in

Crossref

DOI

10.1007/S00213-011-2207-6

reference URL

https://api.crossref.org/works/10.1007/S00213-011-2207-6

retrieved

25 November 2024

Molecular Pharmacology

series ordinal

63

volume

43

page(s)

84

author name string

M Rinaldi-Carmona

publication date

1993

1 reference

stated in

Crossref

DOI

10.1007/S00213-011-2207-6

reference URL

https://api.crossref.org/works/10.1007/S00213-011-2207-6

retrieved

25 November 2024

Identifiers

DOI

10.1007/S00213-011-2207-6

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21340474

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21340474%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

Dimensions Publication ID

1019196520

0 references

PubMed publication ID

21340474

1 reference

stated in

Europe PubMed Central

PubMed publication ID

21340474

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21340474%20AND%20SRC:MED&resulttype=core&format=json

retrieved

23 January 2020

 

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