A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory (Q82437065)

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scientific article published on 08 November 2011

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English	A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory	scientific article published on 08 November 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22069308%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22069308%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

Julia Diegelmann

1

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16 January 2020

Torsten Olszak

2

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16 January 2020

Burkhard Göke

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22069308%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Richard S Blumberg

4

1 reference

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16 January 2020

Stephan Brand

5

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16 January 2020

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publication date

8 November 2011

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16 January 2020

number of pages

13

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

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16 January 2020

287

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16 January 2020

1

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16 January 2020

286-298

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16 January 2020

Analysis by high density cDNA arrays of altered gene expression in human intestinal epithelial cells in response to infection with the invasive enteric bacteria Salmonella

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-gamma-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of two regulatory elements in interferon-gamma-regulated expression of human indoleamine 2,3-dioxygenase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperative role of interferon regulatory factor 1 and p91 (STAT1) response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of group B streptococcal growth by IFN gamma-activated human glioblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma-induced activation of indoleamine 2,3-dioxygenase in cord blood monocyte-derived macrophages inhibits the growth of group B streptococci

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fecal excretion of alpha 2-macroglobulin: a novel marker for disease activity in patients with inflammatory bowel disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for IL-27 in early regulation of Th1 differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DSS-induced colitis is exacerbated in STAT-6 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT6 specific shRNA inhibits proliferation and induces apoptosis in colon cancer HT-29 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-12, IL-23, and IL-27 enhance human beta-defensin-2 production in human keratinocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scavenger receptor gp340 aggregates group A streptococci by binding pili.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflamed intestinal mucosa features a specific epithelial expression pattern of indoleamine 2,3-dioxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leucine-rich repeats of bacterial surface proteins serve as common pattern recognition motifs of human scavenger receptor gp340.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IDO activates regulatory T cells and blocks their conversion into Th17-like T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effect of IL-27 on developing versus committed Th17 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin has a key role in pathogenesis of experimental colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common variants at five new loci associated with early-onset inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indoleamine 2,3-Dioxygenase Mediates the Antiviral Effect of Gamma Interferon against Hepatitis B Virus in Human Hepatocyte-Derived Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DMBT1 is a novel gene induced by IL-22 in ulcerative colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22069308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.294355

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22069308%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22069308%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22069308%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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