Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy (Q80914233)

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4 January 2020

review article

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title

Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy (English)

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4 January 2020

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Annick Desjardins

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4 January 2020

Patrick Y Wen

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4 January 2020

David A Reardon

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4 January 2020

Tracy T Batchelor

series ordinal

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4 January 2020

James J Vredenburgh

series ordinal

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4 January 2020

publication date

1 April 2008

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Expert Opinion on Biological Therapy

4 January 2020

published in

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4 January 2020

volume

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4 January 2020

issue

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4 January 2020

page(s)

541-553

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Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging

4 January 2020

cites work

1 reference

12 December 2020

Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2.

1 reference

12 December 2020

Salvage chemotherapy with CPT-11 for recurrent glioblastoma multiforme

1 reference

12 December 2020

VEGF-Trap: a VEGF blocker with potent antitumor effects

1 reference

12 December 2020

Dynamic susceptibility contrast-enhanced echo-planar imaging of cerebral gliomas. Effect of contrast medium extravasation

1 reference

12 December 2020

Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis

1 reference

12 December 2020

MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy.

1 reference

12 December 2020

Antiangiogenic therapy: a universal chemosensitization strategy for cancer?

1 reference

12 December 2020

18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy

1 reference

12 December 2020

'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis

1 reference

12 December 2020

Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.

1 reference

12 December 2020

Mechanisms of angiogenesis in gliomas

1 reference

12 December 2020

Acidic and basic fibroblast growth factors are present in glioblastoma multiforme

1 reference

12 December 2020

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1 reference

12 December 2020

Recurrent glioblastoma multiforme: advances in treatment and promising drug candidates

1 reference

12 December 2020

Antiangiogenic therapy against experimental glioblastoma using genetically engineered cells producing interferon-alpha, angiostatin, or endostatin

1 reference

12 December 2020

Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice

1 reference

12 December 2020

Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer

1 reference

12 December 2020

Sorafenib in advanced clear-cell renal-cell carcinoma

1 reference

12 December 2020

A perivascular niche for brain tumor stem cells

1 reference

12 December 2020

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

1 reference

12 December 2020

Effect of bevacizumab on radiation necrosis of the brain

1 reference

12 December 2020

Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma

1 reference

12 December 2020

Venous thromboembolism and survival in patients with high-grade glioma

1 reference

12 December 2020

Expression of VEGFR3 in glioma endothelium correlates with tumor grade

1 reference

12 December 2020

Insulin-like growth factor type I biology and targeting in malignant gliomas

1 reference

12 December 2020

VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma.

1 reference

12 December 2020

Epidemiology of venous thromboembolism in 9489 patients with malignant glioma.

1 reference

12 December 2020

Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors

1 reference

12 December 2020

Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging.

1 reference

12 December 2020

Antiangiogenic strategies on defense: on the possibility of blocking rebounds by the tumor vasculature after chemotherapy

1 reference

12 December 2020

A review of micro- and macrovascular analyses in the assessment of tumor-associated vasculature as visualized by MR.

1 reference

12 December 2020

Antiangiogenic and anti-invasive effects of sunitinib on experimental human glioblastoma

1 reference

12 December 2020

Making a tumour's bed: glioblastoma stem cells and the vascular niche.

1 reference

12 December 2020

Hypoxia inducible factor-1 independent pathways in tumor angiogenesis.

1 reference

12 December 2020

Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study

1 reference

12 December 2020

Bevacizumab plus irinotecan in recurrent glioblastoma multiforme

1 reference

12 December 2020

Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials

1 reference

12 December 2020

Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group

1 reference

12 December 2020

Vascular endothelial growth factor expression is independent of hypoxia in human malignant glioma spheroids and tumours

1 reference

12 December 2020

Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression

1 reference

12 December 2020

The risk of venous thromboembolism is increased throughout the course of malignant glioma: an evidence-based review

1 reference

12 December 2020

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

1 reference

12 December 2020

Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption

1 reference

12 December 2020

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

1 reference

12 December 2020

Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.

1 reference

12 December 2020

Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway

1 reference

12 December 2020

Alpha(v)beta3 and alpha(v)beta5 integrin expression in glioma periphery.

1 reference

12 December 2020

Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo.

1 reference

12 December 2020

Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy

1 reference

12 December 2020

Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2.

1 reference

12 December 2020

Tumor angiogenesis of low-grade astrocytomas measured by dynamic susceptibility contrast-enhanced MRI (DSC-MRI) is predictive of local tumor control after radiation therapy.

1 reference

12 December 2020

Low-dose chemotherapy combined with an antiangiogenic drug reduces human glioma growth in vivo.

1 reference

12 December 2020

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 December 2020

Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy

1 reference

12 December 2020

PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter.

1 reference

12 December 2020

Two studies evaluating irinotecan treatment for recurrent malignant glioma using an every-3-week regimen

1 reference

12 December 2020

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

1 reference

12 December 2020

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

1 reference

12 December 2020

The biology of VEGF and its receptors

1 reference

12 December 2020

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis

1 reference

12 December 2020

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1 reference

12 December 2020

Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours

1 reference

12 December 2020

Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms

1 reference

12 December 2020

Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors.

1 reference

12 December 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 December 2020

Angiogenesis in malignant gliomas

1 reference

12 December 2020

The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency

1 reference

12 December 2020

Microvessel density is a prognostic indicator for patients with astroglial brain tumors.

1 reference

12 December 2020

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

12 December 2020

Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets

1 reference

12 December 2020

Isolation of putative progenitor endothelial cells for angiogenesis

1 reference

12 December 2020

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

1 reference

12 December 2020

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor

1 reference

12 December 2020

Platelet: transporter of vascular endothelial growth factor

1 reference

12 December 2020

Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis.

1 reference

12 December 2020

Leukocytes and platelets of patients with cancer contain high levels of vascular endothelial growth factor

1 reference

12 December 2020

Irinotecan therapy in adults with recurrent or progressive malignant glioma

1 reference

12 December 2020

Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation

1 reference

12 December 2020

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

1 reference

12 December 2020

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

1 reference

12 December 2020

Genetic and hypoxic regulation of angiogenesis in gliomas

1 reference

12 December 2020

Combined inhibition of vascular endothelial growth factor and platelet-derived growth factor signaling: effects on the angiogenesis, microcirculation, and growth of orthotopic malignant gliomas.

1 reference

12 December 2020

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

12 December 2020

Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials

1 reference

12 December 2020

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis

1 reference

12 December 2020

Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG.

1 reference

12 December 2020

Phase I study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of PTK787/ZK 222584 administered twice daily in patients with advanced cancer

1 reference

12 December 2020

Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient surv

1 reference

12 December 2020

Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy

1 reference

12 December 2020

Magnetic resonance angiography visualization of abnormal tumor vasculature in genetically engineered mice

1 reference

12 December 2020

Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis

1 reference

12 December 2020

The role of pericytes in blood-vessel formation and maintenance

1 reference

12 December 2020

Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer

1 reference

12 December 2020

Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients

1 reference

12 December 2020

ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors

1 reference

12 December 2020

VEGF as a therapeutic target in cancer

1 reference

12 December 2020

Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer

1 reference

12 December 2020

Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma

1 reference

12 December 2020

Angiogenesis in gliomas: biology and molecular pathophysiology

1 reference

12 December 2020

The role of the extracellular matrix in angiogenesis in malignant glioma tumors

1 reference

12 December 2020

Proteases and glioma angiogenesis.

1 reference

12 December 2020

Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer

1 reference

12 December 2020

Lessons from phase III clinical trials on anti-VEGF therapy for cancer

1 reference

12 December 2020

Antiangiogenic and antitumor effects of bevacizumab in patients with inflammatory and locally advanced breast cancer

1 reference

12 December 2020

Comparison of microvascular permeability measurements, K(trans), determined with conventional steady-state T1-weighted and first-pass T2*-weighted MR imaging methods in gliomas and meningiomas.

1 reference

12 December 2020

Integrins and angiogenesis: a sticky business

1 reference

12 December 2020

Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods?

1 reference

12 December 2020

Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy

1 reference

12 December 2020

A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study.

1 reference

12 December 2020

Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain

1 reference

12 December 2020

Preuss Resident Research Award: bone marrow-derived Flk-1-expressing CD34+ cells contribute to the endothelium of tumor vessels in mouse brain.

1 reference

12 December 2020

Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker

1 reference

12 December 2020

Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor

1 reference

12 December 2020

Vascular endothelial growth factor signaling pathways: therapeutic perspective

1 reference

12 December 2020

The multifaceted circulating endothelial cell in cancer: towards marker and target identification.

1 reference

12 December 2020

Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging

1 reference

12 December 2020

Phase I clinical and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma

1 reference

12 December 2020

Invasion as limitation to anti-angiogenic glioma therapy

1 reference

12 December 2020

Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis

1 reference

12 December 2020

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

1 reference

12 December 2020

Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms

1 reference

12 December 2020

Phase 2 study of weekly irinotecan in adults with recurrent malignant glioma: final report of NABTT 97-11.

1 reference

12 December 2020

1 reference

12 December 2020

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

1 reference

12 December 2020

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

1 reference

12 December 2020

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma

1 reference

12 December 2020

Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells

1 reference

12 December 2020

Integrin signalling during tumour progression

1 reference

12 December 2020

Use of soluble recombinant decoy receptor vascular endothelial growth factor trap (VEGF Trap) to inhibit vascular endothelial growth factor activity

1 reference

12 December 2020

Tumor angiogenesis: therapeutic implications

1 reference

12 December 2020

Tumor angiogenesis: a quantitative method for histologic grading

1 reference

12 December 2020

Response criteria for phase II studies of supratentorial malignant glioma

1 reference

12 December 2020

Identifiers

DOI

10.1517/14712598.8.4.541

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18352856%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18352856%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

18352856

1 reference

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