IL-2Rbeta links IL-2R signaling with Foxp3 expression (Q80455481)

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31 December 2019

title

IL-2Rbeta links IL-2R signaling with Foxp3 expression (English)

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31 December 2019

David M Soper

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31 December 2019

Deborah J Kasprowicz

series ordinal

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31 December 2019

Steven F Ziegler

series ordinal

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31 December 2019

publication date

1 July 2007

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European Journal of Immunology

31 December 2019

published in

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31 December 2019

volume

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31 December 2019

issue

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31 December 2019

page(s)

1817-1826

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Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education

31 December 2019

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

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Control of regulatory T cell development by the transcription factor Foxp3

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Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

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Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation

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Molecular cloning of cDNA encoding human interleukin-2 receptor

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Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor

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Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

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Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells

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7 January 2021

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

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7 January 2021

CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10

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7 January 2021

Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo

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7 January 2021

Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors

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CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

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7 January 2021

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

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Interleukin-2-dependent mechanisms of tolerance and immunity in vivo

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7 January 2021

The amount of scurfin protein determines peripheral T cell number and responsiveness

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7 January 2021

Impaired T cell receptor signaling in Foxp3+ CD4 T cells

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7 January 2021

Both integrated and differential regulation of components of the IL-2/IL-2 receptor system

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7 January 2021

A function for interleukin 2 in Foxp3-expressing regulatory T cells

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7 January 2021

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

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7 January 2021

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

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7 January 2021

SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

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7 January 2021

Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation

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7 January 2021

Functional dissection of the cytoplasmic subregions of the IL-2 receptor betac chain in primary lymphocyte populations

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7 January 2021

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

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7 January 2021

Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells

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7 January 2021

Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor

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7 January 2021

Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis

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7 January 2021

IFN-gamma controls the generation/activation of CD4+ CD25+ regulatory T cells in antitumor immune response.

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7 January 2021

Dynamic regulation of FoxP3 expression controls the balance between CD4+ T cell activation and cell death

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7 January 2021

Identifiers

DOI

10.1002/EJI.200737101

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17559173%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference

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