Wnt signaling and the regulation of bone mass (Q80374328)

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scientific article published on 01 June 2007

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English	Wnt signaling and the regulation of bone mass	scientific article published on 01 June 2007

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Europe PubMed Central

PubMed publication ID

17521509

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

retrieved

31 December 2019

title

Wnt signaling and the regulation of bone mass (English)

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Europe PubMed Central

PubMed publication ID

17521509

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

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31 December 2019

author name string

Roland Baron

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1

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Europe PubMed Central

PubMed publication ID

17521509

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

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31 December 2019

Georges Rawadi

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2

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Europe PubMed Central

PubMed publication ID

17521509

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

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31 December 2019

language of work or name

English

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publication date

1 June 2007

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Europe PubMed Central

PubMed publication ID

17521509

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

retrieved

31 December 2019

published in

Current osteoporosis reports

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Europe PubMed Central

PubMed publication ID

17521509

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

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31 December 2019

volume

5

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Europe PubMed Central

PubMed publication ID

17521509

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

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31 December 2019

issue

2

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Europe PubMed Central

PubMed publication ID

17521509

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

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31 December 2019

page(s)

73-80

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Europe PubMed Central

PubMed publication ID

17521509

reference URL

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31 December 2019

cites work

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

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PubMed

reference URL

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12 December 2020

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LRP6 mutation in a family with early coronary disease and metabolic risk factors

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PubMed

reference URL

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12 December 2020

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Multiple roles of mesenchymal -catenin during murine limb patterning

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PubMed

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12 December 2020

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

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Regulation of osteoblastogenesis and bone mass by Wnt10b

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PubMed

reference URL

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12 December 2020

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A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of GSK-3: a cellular multiprocessor

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

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Prostate cancer cells promote osteoblastic bone metastases through Wnts

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

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Cellular and molecular mechanisms of synovial joint and articular cartilage formation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

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Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

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Minireview: the OPG/RANKL/RANK system

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of the LRP5 gene to normal variation in peak BMD in women

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

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Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOST is a target gene for PTH in bone

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of genes regulated during osteoblastic differentiation by genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced relative risk of fractures among users of lithium

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of cathepsin K inhibitors for osteoporosis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression profile of osteoblast lineage at defined stages of differentiation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High bone density due to a mutation in LDL-receptor-related protein 5

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterozygous mutations in the LDL receptor-related protein 5 (LRP5) gene are associated with primary osteoporosis in children.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High bone mass in mice expressing a mutant LRP5 gene

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin K, osteoclastic resorption, and osteoporosis therapy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical stimulation in vivo reduces osteocyte expression of sclerostin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dickkopf-1 is a master regulator of joint remodeling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/beta-catenin signaling in development and disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role of beta-catenin in postnatal bone acquisition

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/17521509

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S11914-007-0006-0

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17521509

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

retrieved

31 December 2019

Dimensions Publication ID

1037728252

0 references

PubMed publication ID

17521509

1 reference

stated in

Europe PubMed Central

PubMed publication ID

17521509

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17521509%20AND%20SRC:MED&resulttype=core&format=json

retrieved

31 December 2019

 

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