DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination (Q89952829)

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scientific article published on 26 February 2020

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English	DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination	scientific article published on 26 February 2020

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Europe PubMed Central

PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

retrieved

10 April 2020

title

DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair steps of V(D)J recombination (English)

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Europe PubMed Central

PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

retrieved

10 April 2020

author name string

Z Anne Esguerra

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1

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Europe PubMed Central

PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

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10 April 2020

Go Watanabe

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2

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PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

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10 April 2020

Cindy Y Okitsu

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3

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PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

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10 April 2020

Chih-Lin Hsieh

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4

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Europe PubMed Central

PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

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10 April 2020

Michael R Lieber

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5

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Europe PubMed Central

PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

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10 April 2020

publication date

26 February 2020

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Europe PubMed Central

PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

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10 April 2020

published in

Molecular Immunology

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Europe PubMed Central

PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

retrieved

10 April 2020

volume

120

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Europe PubMed Central

PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

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10 April 2020

page(s)

93-100

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Europe PubMed Central

PubMed publication ID

32113132

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

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10 April 2020

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DEAE-dextran enhances electroporation of mammalian cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

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The basis for the mechanistic bias for deletional over inversional V(D)J recombination

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

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Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

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Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unequal signal and coding joint formation in human V(D)J recombination

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of V(D)J recombination in double-strand break repair mutants

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of a test for identification of Arabian horses heterozygous for the severe combined immunodeficiency trait

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA-PK is essential only for coding joint formation in V(D)J recombination

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

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Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

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Competitive and noncompetitive inhibition of the DNA-dependent protein kinase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

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inferred from PubMed ID database lookup

Autosomal recessive severe combined immunodeficiency of Jack Russell terriers

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA-PKcs deficiency in human: long predicted, finally found.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

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Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PRKDC mutations in a SCID patient with profound neurological abnormalities

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the DNA endonuclease ARTEMIS also has intrinsic 5'-exonuclease activity

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting DNA-Dependent Protein Kinase for Cancer Therapy.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/32113132

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12 December 2020

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Identifiers

DOI

10.1016/J.MOLIMM.2020.01.018

1 reference

stated in

Europe PubMed Central

PubMed publication ID

32113132

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

retrieved

10 April 2020

PMC publication ID

7184946

0 references

PubMed publication ID

32113132

1 reference

stated in

Europe PubMed Central

PubMed publication ID

32113132

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32113132%20AND%20SRC:MED&resulttype=core&format=json

retrieved

10 April 2020

 

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