Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2 (Q89942278)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32110554%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2 (English)

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9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

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9 April 2020

Tong Liu

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9 April 2020

Sainan Li

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9 April 2020

Qiang Yu

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9 April 2020

Jingjing Li

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9 April 2020

Jiaojiao Chen

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9 April 2020

Yuting Zhou

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9 April 2020

Jie Ji

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9 April 2020

Fan Wang

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9 April 2020

Weiqi Dai

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9 April 2020

Xiaoming Fan

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9 April 2020

Jianye Wu

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9 April 2020

publication date

18 February 2020

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Journal of hepatocellular carcinoma

9 April 2020

published in

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9 April 2020

volume

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9 April 2020

page(s)

19-31

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Creative Commons Attribution-NonCommercial 3.0 Unported

9 April 2020

start time

1 February 2020

1 reference

April 2022 Public Data File from Crossref

copyrighted

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cites work

Hepatitis B and Hepatocellular Carcinoma

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Molecular mechanisms of hepatocellular carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

PKM2 regulates Gli1 expression in hepatocellular carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

THE METABOLISM OF TUMORS IN THE BODY

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Tumor glycolysis as a target for cancer therapy: progress and prospects

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Protection of human keratinocytes from UVB-induced inflammation using root extract of Lithospermum erythrorhizon

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

The protective effects of shikonin on hepatic ischemia/reperfusion injury are mediated by the activation of the PI3K/Akt pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin enhances sensitization of gefitinib against wild-type EGFR non-small cell lung cancer via inhibition PKM2/stat3/cyclinD1 signal pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Sarcoma-Targeting Peptide-Decorated Polypeptide Nanogel Intracellularly Delivers Shikonin for Upregulated Osteosarcoma Necroptosis and Diminished Pulmonary Metastasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

RIP1 and RIP3 contribute to shikonin-induced DNA double-strand breaks in glioma cells via increase of intracellular reactive oxygen species

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin inhibits the growth of human prostate cancer cells via modulation of the androgen receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Anti-tumor activity of Shikonin against afatinib resistant non-small cell lung cancer via negative regulation of PI3K/Akt signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

The Critical Role of PTEN/PI3K/AKT Signaling Pathway in Shikonin-Induced Apoptosis and Proliferation Inhibition of Chronic Myeloid Leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin exerts antitumor activity in Burkitt's lymphoma by inhibiting C-MYC and PI3K/AKT/mTOR pathway and acts synergistically with doxorubicin

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Overexpression of Pyruvate Kinase Type M2 (PKM2) Promotes Ovarian Cancer Cell Growth and Survival Via Regulation of Cell Cycle Progression Related with Upregulated CCND1 and Downregulated CDKN1A Expression.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Knockdown of PKM2 Suppresses Tumor Growth and Invasion in Lung Adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Effects of shRNA-Mediated Silencing of PKM2 Gene on Aerobic Glycolysis, Cell Migration, Cell Invasion, and Apoptosis in Colorectal Cancer Cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Effects of PKM2 Gene Silencing on the Proliferation and Apoptosis of Colorectal Cancer LS-147T and SW620 Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

PKM2 promotes glucose metabolism through a let-7a-5p/Stat3/hnRNP-A1 regulatory feedback loop in breast cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Lenvatinib for the treatment of unresectable hepatocellular carcinoma: evidence to date

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin sensitizes wild‑type EGFR NSCLC cells to erlotinib and gefitinib therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin enhances Adriamycin antitumor effects by inhibiting efflux pumps in A549 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

Shikonin potentiates the effect of arsenic trioxide against human hepatocellular carcinoma in vitro and in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.2147%2FJHC.S237614

MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/32110554

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/32110554

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Combined hepatocellular cholangiocarcinoma (cHCC-CC): an update of genetics, molecular biology, and therapeutic interventions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/32110554

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2147/JHC.S237614

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32110554%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

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9 April 2020

PubMed publication ID

32110554

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32110554%20AND%20SRC:MED&resulttype=core&format=json