The Smyd Family of Methyltransferases: Role in Cardiac and Skeletal Muscle Physiology and Pathology (Q87768403)

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scientific article published on 13 December 2017

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English	The Smyd Family of Methyltransferases: Role in Cardiac and Skeletal Muscle Physiology and Pathology	scientific article published on 13 December 2017

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scholarly article

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Europe PubMed Central

PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

retrieved

16 March 2020

title

The Smyd Family of Methyltransferases: Role in Cardiac and Skeletal Muscle Physiology and Pathology (English)

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Europe PubMed Central

PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

retrieved

16 March 2020

main subject

muscle physiology

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inferred from title

author name string

Christopher Tracy

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1

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Europe PubMed Central

PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

Junco S Warren

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2

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Europe PubMed Central

PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

Marta Szulik

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3

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5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

Li Wang

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4

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Europe PubMed Central

PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

June Garcia

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5

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Europe PubMed Central

PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

retrieved

16 March 2020

Aman Makaju

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6

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5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

Kristi Russell

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7

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PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

Mickey Miller

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8

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PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

Sarah Franklin

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9

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Europe PubMed Central

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5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

publication date

13 December 2017

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Europe PubMed Central

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5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

published in

Current Opinion in Physiology

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Europe PubMed Central

PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

volume

1

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Europe PubMed Central

PMC publication ID

5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

page(s)

140-152

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Europe PubMed Central

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5807017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

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16 March 2020

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The Bop gene adjacent to the mouse CD8b gene encodes distinct zinc-finger proteins expressed in CTLs and in muscle

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12 December 2020

based on heuristic

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Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

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PubMed

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12 December 2020

based on heuristic

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m-Bop, a repressor protein essential for cardiogenesis, interacts with skNAC, a heart- and muscle-specific transcription factor

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

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Hallmarks of ion channel gene expression in end-stage heart failure

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12 December 2020

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SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

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Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex

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12 December 2020

based on heuristic

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Muscle-specific expression of the smyd1 gene is controlled by its 5.3-kb promoter and 5'-flanking sequence in zebrafish embryos.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repression of p53 activity by Smyd2-mediated methylation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C/EBPalphap30 plays transcriptional regulatory roles distinct from C/EBPalphap42.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

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Thioredoxin1 as a negative regulator of cardiac hypertrophy

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

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A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

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Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

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Genome-wide histone methylation profile for heart failure

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of Smyd4 as a potential tumor suppressor gene involved in breast cancer development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac deletion of Smyd2 is dispensable for mouse heart development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The variations of BOP gene in hypertrophic cardiomyopathy.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation of the retinoblastoma tumor suppressor by SMYD2

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site Architecture

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural insights into the autoinhibition and posttranslational activation of histone methyltransferase SmyD3

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal Structures of Histone and p53 Methyltransferase SmyD2 Reveal a Conformational Flexibility of the Autoinhibitory C-Terminal Domain

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The myosin-interacting protein SMYD1 is essential for sarcomere organization

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct epigenomic features in end-stage failing human hearts

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/29435515

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SMYD2 is induced during cell differentiation and participates in early development

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smyd1b is required for skeletal and cardiac muscle function in zebrafish

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SMYD3 as an oncogenic driver in prostate cancer by stimulation of androgen receptor transcription

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and functional characterization of Smyd1a in myofibril organization of skeletal muscles

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A draft map of the human proteome

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The E3 SUMO ligase Nse2 regulates sumoylation and nuclear-to-cytoplasmic translocation of skNAC-Smyd1 in myogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SMYD proteins: key regulators in skeletal and cardiac muscle development and function

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of SMYD2 contributes to malignant outcome in gastric cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of substrates for a SET domain lysine methyltransferase predicted by multistate computational protein design.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and function of SET and MYND domain-containing proteins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical roles of non-histone protein lysine methylation in human tumorigenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone methylations in heart development, congenital and adult heart diseases

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

skNAC and Smyd1 in transcriptional control

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective myogenesis in the absence of the muscle-specific lysine methyltransferase SMYD1.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SMYD1, an SRF-Interacting Partner, Is Involved in Angiogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smyd3 open & closed lock mechanism for substrate recruitment: The hinge motion of C-terminal domain inferred from μ-second molecular dynamics simulations

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smyd5 plays pivotal roles in both primitive and definitive hematopoiesis during zebrafish embryogenesis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Explaining the autoinhibition of the SMYD enzyme family: A theoretical study.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chromatin-binding protein Smyd1 restricts adult mammalian heart growth

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/29435515

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1016/J.COPHYS.2017.10.001

1 reference

stated in

Europe PubMed Central

PMC publication ID

5807017

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

retrieved

16 March 2020

PMC publication ID

5807017

1 reference

stated in

Europe PubMed Central

PMC publication ID

5807017

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

retrieved

16 March 2020

PubMed publication ID

29435515

1 reference

stated in

Europe PubMed Central

PMC publication ID

5807017

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29435515%20AND%20SRC:MED&resulttype=core&format=json

retrieved

16 March 2020

 

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