Targeting virulence: can we make evolution-proof drugs? (Q87435859)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625893%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

review article

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title

Targeting virulence: can we make evolution-proof drugs? (English)

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10 March 2020

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10 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625893%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

Stephen P Diggle

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10 March 2020

Roman Popat

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10 March 2020

publication date

1 April 2014

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Nature Reviews Microbiology

10 March 2020

published in

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10 March 2020

volume

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10 March 2020

issue

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10 March 2020

page(s)

300-308

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Origins and evolution of antibiotic resistance

10 March 2020

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Antibiotic resistance is ancient

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Novel classes of antibiotics or more of the same?

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Targeting virulence: a new paradigm for antimicrobial therapy

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Enhanced persistence in the colonic microbiota of Escherichia coli strains belonging to phylogenetic group B2: role of virulence factors and adherence to colonic cells

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Pathogenicity-associated islands in extraintestinal pathogenic Escherichia coli are fitness elements involved in intestinal colonization

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Fitness costs associated with unnecessary virulence factors and life history traits: evolutionary insights from the potato late blight pathogen Phytophthora infestans

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Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice

31 March 2020

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A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence

31 March 2020

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Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Quorum-quenching acylase reduces the virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans infection model

31 March 2020

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31 March 2020

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31 March 2020

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Inhibitors and antagonists of bacterial quorum sensing

31 March 2020

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Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing

31 March 2020

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The control of experimental Escherichia coli diarrhoea in calves by means of bacteriophages.

31 March 2020

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12 December 2020

Spatial distribution of microbial communities in the cystic fibrosis lung

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Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria

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Analogs of the autoinducer 3-oxooctanoyl-homoserine lactone strongly inhibit activity of the TraR protein of Agrobacterium tumefaciens.

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12 December 2020

Identifiers

DOI

10.1038/NRMICRO3232

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625893%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24625893%20AND%20SRC:MED&resulttype=core&format=json