The Interleukin-4-Receptor: From Recognition Mechanism to Pharmacological Target Structure (Q73068204)

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1 November 2019

title

The Interleukin-4-Receptor: From Recognition Mechanism to Pharmacological Target Structure (English)

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1 November 2019

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1 November 2019

Reinemer P

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1 November 2019

Sebald W

series ordinal

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1 November 2019

language of work or name

English

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publication date

1 August 2000

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Angewandte Chemie International Edition

1 November 2019

published in

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1 November 2019

volume

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issue

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1 November 2019

page(s)

2834-2846

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Dimerization of cell surface receptors in signal transduction

1 November 2019

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Interleukin-4 and interleukin-13: their similarities and discrepancies

21 January 2018

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Requirement for IL-13 independently of IL-4 in experimental asthma

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Interleukin-13: central mediator of allergic asthma

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Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

21 January 2018

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An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

21 January 2018

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IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis.

21 January 2018

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Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses

21 January 2018

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The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms

21 January 2018

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Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily

21 January 2018

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Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

21 January 2018

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21 January 2018

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Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

21 January 2018

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21 January 2018

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Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex

21 January 2018

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A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Regulation of antibody class switching to IgE: characterization of an IL-4-responsive region in the immunoglobulin heavy-chain germline epsilon promoter

21 January 2018

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Independent pathways for de-repression of the mouse Ig heavy chain germ-line epsilon promoter: an IL-4 NAF/NF-IL-4 site as a context-dependent negative element

21 January 2018

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The human IgE germline promoter is regulated by interleukin-4, interleukin-13, interferon-alpha and interferon-gamma via an interferon-gamma-activated site and its flanking regions

21 January 2018

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Interferon-gamma-induced factor binding to the interleukin-4-responsive element of CD23b promoter in human tonsillar mononuclear cells: role in transient up-regulation of the interleukin-4-induced CD23b mRNA.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

21 January 2018

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21 January 2018

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A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain

21 January 2018

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21 January 2018

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Structure of a Fibronectin Type III Domain from Tenascin Phased by MAD Analysis of the Selenomethionyl Protein

21 January 2018

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Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy

21 January 2018

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Human interleukin 4. The solution structure of a four-helix bundle protein

21 January 2018

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Crystal structure of human recombinant interleukin-4 at 2.25 A resolution

21 January 2018

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The interleukin-4 site-2 epitope determining binding of the common receptor gamma chain

21 January 2018

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IL-4 receptor complexes containing or lacking the gamma C chain are inhibited by an overlapping set of antagonistic IL-4 mutant proteins

21 January 2018

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The interpretation of protein structures: Estimation of static accessibility

21 January 2018

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

21 January 2018

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Receptor binding properties of four-helix-bundle growth factors deduced from electrostatic analysis.

21 January 2018

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Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency

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A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction

21 January 2018

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10.1002/1521-3773(20000818)39:16<2834::AID-ANIE2834>3.0.CO;2-K

21 January 2018

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1 November 2019

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