Cyclosporin A inhibits T cell receptor-induced interleukin-2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein kinase C isoenzyme, protein kinase C-bet (Q72650418)

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scientific article published on 01 December 1993

Language	Label	Description	Also known as
English	Cyclosporin A inhibits T cell receptor-induced interleukin-2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein kinase C isoenzyme, protein kinase C-bet	scientific article published on 01 December 1993

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scholarly article

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28 October 2019

Cyclosporin A inhibits T cell receptor-induced interleukin-2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein kinase C isoenzyme, protein kinase C-beta (English)

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28 October 2019

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author name string

Szamel M

1

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28 October 2019

Bartels F

2

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28 October 2019

Resch K

3

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28 October 2019

publication date

1 December 1993

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28 October 2019

European Journal of Immunology

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28 October 2019

23

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28 October 2019

12

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28 October 2019

3072-3081

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28 October 2019

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Contingent genetic regulatory events in T lymphocyte activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

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The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

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https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

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T-lymphocyte activation: the role of protein kinase C and the bifurcating inositol phospholipid signal transduction pathway

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7 January 2021

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Cyclosporin A does not inhibit the PHA-stimulated increase in intracellular Ca2+ concentration but inhibits the increase in E-rosette receptor (CD2) expression and appearance of interleukin-2 receptors (CD25)

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Cyclosporine does not prevent cytoplasmic calcium changes associated with lymphocyte activation.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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The influence of cyclosporin A on the alternative pathways of human T cell activation in vitro

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

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The mechanism of action of cyclosporin A and FK506

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction in T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase C and T cell activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Activation of resting human T cells requires prolonged stimulation of protein kinase C

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

T cell activation induced by anti-CD3 antibodies requires prolonged stimulation of protein kinase C.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

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Activation signals in human lymphocytes: interleukin 2 synthesis and expression of high affinity interleukin 2 receptors require differential signalling for the activation of protein kinase C

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

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Inhibition of lymphocyte activation by cyclosporin A: interference with the early activation of the membrane phospholipid metabolism in rabbit lymphocytes stimulated with concanavalin A, anti-rabbit immunoglobulin or the Ca2+ ionophore A 23187

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

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Gaining access to the cytosol: the technique and some applications of electropermeabilization

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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FKBP, the binding protein for the immunosuppressive drug, FK-506, is not an inhibitor of protein kinase C activity

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

Receptor-coupled phospholipase D and its inhibition

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Polyunsaturated fatty acids are enriched in the plasma membranes of mitogen-stimulated T-lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

Mode of activation and kinetic properties of three distinct forms of protein kinase C from rat brain

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

Phospholipid metabolism of stimulated lymphocytes. Preferential incorporation of polyunsaturated fatty acids into plasma membrane phospholipid upon stimulation with concanavalin A

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

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Protein kinase C, calcium and phospholipid degradation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction and gene control

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1 reference

https://api.crossref.org/works/10.1002%2FEJI.1830231205

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/EJI.1830231205

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8258320%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8258320%20AND%20SRC:MED&resulttype=core&format=json

28 October 2019

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