A hybrid modular polyketide synthase obtained by domain swapping (Q71824462)

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21 October 2019

title

A hybrid modular polyketide synthase obtained by domain swapping (English)

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21 October 2019

M Oliynyk

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21 October 2019

M J Brown

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21 October 2019

J Cortés

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21 October 2019

J Staunton

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21 October 2019

P F Leadlay

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21 October 2019

publication date

1 October 1996

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21 October 2019

published in

Chemistry and Biology

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21 October 2019

volume

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21 October 2019

issue

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21 October 2019

page(s)

833-839

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Molecular genetics of polyketides and its comparison to fatty acid biosynthesis

21 October 2019

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Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics

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Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

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Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence

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Repeated polyketide synthase modules involved in the biosynthesis of a heptaene macrolide by Streptomyces sp. FR-008.

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Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

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Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

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7 January 2021

Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin

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Significance of anthraquinone formation resulting from the cloning of actinorhodin genes in heterologous streptomycetes

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7 January 2021

Engineered biosynthesis of novel polyketides

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7 January 2021

Engineered biosynthesis of novel polyketides: stereochemical course of two reactions catalyzed by a polyketide synthase

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Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

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Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

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A mutant generated by expression of an engineered DEBS 1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coelicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate

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7 January 2021

Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases

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7 January 2021

Evidence for a double-helical structure for modular polyketide synthases.

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Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

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Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases

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7 January 2021

Polyketide synthesis in vitro on a modular polyketide synthase

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Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

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7 January 2021

Conformational analysis. 130. MM2. A hydrocarbon force field utilizing V1 and V2 torsional terms

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7 January 2021

Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

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9 March 2024

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Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

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9 March 2024

https://opencitations.net/index/api/v1/citations/10.1002/J.1460-2075.1989.TB08414.X

Identifiers

DOI

10.1016/S1074-5521(96)90069-1

1 reference

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21 October 2019

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