Cellular and molecular determinants of cisplatin resistance (Q77809152)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893624%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

review article

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title

Cellular and molecular determinants of cisplatin resistance (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893624%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893624%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

publication date

1 September 1998

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893624%20AND%20SRC:MED&resulttype=core&format=json

European Journal of Cancer

8 December 2019

published in

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8 December 2019

volume

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8 December 2019

issue

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8 December 2019

page(s)

1535-1542

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893624%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

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Drugs five years later. Cisplatin

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Cellular accumulation of the anticancer agent cisplatin: a review

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cis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells

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7 January 2021

Reevaluation of interaction of cis-dichloro(ethylenediamine)platinum(II) with DNA

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Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II)

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Increased sensitivity of UV-repair-deficient human cells to DNA bound platinum products which unlike thymine dimers are not recognized by an endonuclease extracted from Micrococcus luteus

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Enhanced DNA repair and resistance to cisplatin in human ovarian cancer

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Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation

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Role of platinum-DNA adduct formation and removal in cisplatin resistance in human ovarian cancer cell lines

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An electron-microscope study of the mode of cell death induced by cancer-chemotherapeutic agents in populations of proliferating normal and neoplastic cells

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Cell death: the significance of apoptosis

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Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

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DNA damage tolerance, mismatch repair and genome instability

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Identification of mismatch repair genes and their role in the development of cancer

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Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line

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Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins.

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Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

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Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor).

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HMG1 protein inhibits the translesion synthesis of the major DNA cisplatin adduct by cell extracts 1 1Edited by M. Yaniv

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Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin

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7 January 2021

The ORD1 gene encodes a transcription factor involved in oxygen regulation and is identical to IXR1, a gene that confers cisplatin sensitivity to Saccharomyces cerevisiae

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Resistance to alkylating agents and cisplatin: insights from ovarian carcinoma model systems

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Active efflux system for cisplatin in cisplatin-resistant human KB cells

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Characterization of the reactions of platinum antitumor agents with biologic and nonbiologic sulfur-containing nucleophiles

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Effect of buthionine sulfoximine on PtII and PtIV drug accumulation and the formation of glutathione conjugates in human ovarian-carcinoma cell lines

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Cross-linking of glutathione to DNA by cancer chemotherapeutic platinum coordination complexes

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Overexpression of metallothionein confers resistance to anticancer drugs.

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7 January 2021

Metallothionein-mediated cisplatin resistance in human ovarian carcinoma cells.

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Metallothionein gene expression and resistance to cisplatin in human ovarian cancer

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Effect of glutathione and its related enzymes on chemosensitivity of renal cell carcinoma and bladder carcinoma cell lines.

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The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines

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7 January 2021

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis

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Cellular glutathione (GSH) and glutathione S-transferase (GST) activity in human ovarian tumor biopsies following exposure to alkylating agents

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Gene specific DNA repair

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Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines

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Enhanced DNA repair and tolerance of DNA damage associated with resistance to cis-diammine-dichloroplatinum (II) after in vitro exposure of a human teratoma cell line to fractionated X-irradiation.

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Wild-type p53 is a cell cycle checkpoint determinant following irradiation

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WAF1, a potential mediator of p53 tumor suppression

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Abrogation of apoptosis induced by DNA-damaging agents in human bladder-cancer cell lines with p21/WAF1/CIP1 and/or p53 gene alterations

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7 January 2021

Identification of p53 genetic suppressor elements which confer resistance to cisplatin

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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Bcl-2 and the regulation of programmed cell death

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Apoptosis in cancer therapy: crossing the threshold

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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Cisplatin-induced apoptosis and p53 gene status in a cisplatin-resistant human ovarian carcinoma cell line

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7 January 2021

p53 tagged sites from human genomic DNA.

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Determinants of Cisplatin Sensitivity in Normal versus Spontaneously Transformed Rat Ovarian Surface Epithelial Cells

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Characterization of high mobility group protein binding to cisplatin-damaged DNA

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The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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Depletion of Glutathione in Normal and Malignant Human Cells In Vivo by Buthionine Sulfoximine: Clinical and Biochemical Results

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Phase I clinical trial of intravenous L-buthionine sulfoximine and melphalan: an attempt at modulation of glutathione

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The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo

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Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna

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Effect of ifosfamide on intracellular glutathione levels in peripheral blood lymphocytes and its correlation with therapeutic response in patients with advanced ovarian cancer

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7 January 2021

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893624%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9893624%20AND%20SRC:MED&resulttype=core&format=json