CD4 dimerization and oligomerization: implications for T-cell function and structure-based drug design (Q77454757)

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5 December 2019

title

CD4 dimerization and oligomerization: implications for T-cell function and structure-based drug design (English)

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5 December 2019

S Li

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5 December 2019

T Satoh

series ordinal

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5 December 2019

R Korngold

series ordinal

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5 December 2019

Z Huang

series ordinal

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5 December 2019

publication date

1 October 1998

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5 December 2019

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5 December 2019

volume

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5 December 2019

issue

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5 December 2019

page(s)

455-462

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The structure of the CD4 and CD8 genes

5 December 2019

cites work

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

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Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2

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7 January 2021

Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation

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7 January 2021

Mouse CD4 binds MHC class II with extremely low affinity

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7 January 2021

Dimeric association and segmental variability in the structure of human CD4

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Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site

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Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules

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Synthetic peptides derived from the fourth domain of CD4 antagonize off function and inhibit T cell activation

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7 January 2021

The MHC-binding and gp120-binding functions of CD4 are separable

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A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitis

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Increased expression of protein kinase C beta activates ERK3.

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Synthetic CD4 exocyclic peptides antagonize CD4 holoreceptor binding and T cell activation

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7 January 2021

Bioactive peptide design based on protein surface epitopes. A cyclic heptapeptide mimics CD4 domain 1 CC' loop and inhibits CD4 biological function

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7 January 2021

Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution

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7 January 2021

Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors

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7 January 2021

Molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-Å resolution

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7 January 2021

Prediction of the structure of a receptor-protein complex using a binary docking method

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7 January 2021

The structural basis of CD4-MHC class II interactions: coreceptor contributions to T cell receptor antigen recognition and oligomerization-dependent signal transduction.

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7 January 2021

The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands

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7 January 2021

CD4 augments the response of a T cell to agonist but not to antagonist ligands

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7 January 2021

The structure of MHC class II: a role for dimer of dimers

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7 January 2021

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

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MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

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7 January 2021

HLA-DR polymorphism affects the interaction with CD4

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7 January 2021

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7 January 2021

Signal transduction by receptors with tyrosine kinase activity

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7 January 2021

X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II

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7 January 2021

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

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7 January 2021

T cell receptor antagonists and partial agonists

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7 January 2021

Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation

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7 January 2021

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7 January 2021

Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity

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Ligands for the T-cell receptor: hard times for avidity models

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Immunoglobulin superfamily proteins: structure, mechanisms, and drug discovery

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Identification of the CD8 DE loop as a surface functional epitope. Implications for major histocompatibility complex class I binding and CD8 inhibitor design

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7 January 2021

Crystal structure of the beta chain of a T cell antigen receptor

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7 January 2021

Crystal structure of the V alpha domain of a T cell antigen receptor

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7 January 2021

10.1016/S0167-5699(98)01325-5

Identifiers

DOI

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5 December 2019

1 reference

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