Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation (Q62868028)

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scientific article published on 23 August 2018

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English	Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation	scientific article published on 23 August 2018

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19 April 2020

Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation (English)

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19 April 2020

brain development

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tuberous sclerosis

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tuberous sclerosis 1

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4

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19 April 2020

Gabriella D'Arcangelo

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Gabriella D'Arcangelo

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Avery J Zucco

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19 April 2020

Valentina Dal Pozzo

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19 April 2020

Alina Afinogenova

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23 August 2018

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19 April 2020

Molecular and Cellular Neuroscience

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19 April 2020

92

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19 April 2020

149-163

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19 April 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6250058/fullTextXML

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Autism and tuberous sclerosis

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https://pubmed.ncbi.nlm.nih.gov/30144504

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Epidemiology of tuberous sclerosis

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https://pubmed.ncbi.nlm.nih.gov/30144504

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A prevalence study of autism in tuberous sclerosis

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https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

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Loss of heterozygosity in tuberous sclerosis hamartomas.

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https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

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Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors

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https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

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Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

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https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

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Endogenous IGF-1 regulates the neuronal differentiation of adult stem cells

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https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

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Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

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https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

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Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

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Markers of cellular proliferation are expressed in cortical tubers

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https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Genotype and psychological phenotype in tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Bioconductor: open software development for computational biology and bioinformatics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Mouse models of tuberous sclerosis complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Cell-cycle control and cortical development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A complex interplay between Akt, TSC2 and the two mTOR complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Tsc2-Rheb signaling regulates EphA-mediated axon guidance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Reprogramming of T cells from human peripheral blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Analysis of TSC cortical tubers by deep sequencing of TSC1, TSC2 and KRAS demonstrates that small second-hit mutations in these genes are rare events

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

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Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR: A pathogenic signaling pathway in developmental brain malformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational research: Rett syndrome and tuberous sclerosis complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytoarchitectural alterations are widespread in cerebral cortex in tuberous sclerosis complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutrient signaling to mTOR and cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic translation of iPSCs for treating neurological disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient and rapid derivation of primitive neural stem cells and generation of brain subtype neurons from human pluripotent stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental brain abnormalities in tuberous sclerosis complex: a comparative tissue analysis of cortical tubers and perituberal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulatory mechanism of neurogenesis by IGF-1 in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGF-1 promotes Brn-4 expression and neuronal differentiation of neural stem cells via the PI3K/Akt pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuberous sclerosis associated neuropsychiatric disorders (TAND) and the TAND Checklist

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain(123).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Near-optimal probabilistic RNA-seq quantification

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Partially Mimicked Development of TSC2 Neurological Abnormalities

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AKT/PKB Signaling: Navigating the Network

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential analysis of RNA-seq incorporating quantification uncertainty

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30144504

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MCN.2018.08.004

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19 April 2020

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Europe PubMed Central

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19 April 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30144504%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

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