Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells (Q62746006)

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scientific article published on 01 June 1999

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English	Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells	scientific article published on 01 June 1999

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10376521%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10376521%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

breast carcinoma

1 reference

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inferred from title

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Albert J Fornace

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10376521%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

author name string

Huang Y

1

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9 December 2019

Sheikh MS

2

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9 December 2019

Holbrook NJ

4

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9 December 2019

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publication date

1 June 1999

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9 December 2019

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10376521%20AND%20SRC:MED&resulttype=core&format=json

9 December 2019

18

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9 December 2019

23

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9 December 2019

3431-3439

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9 December 2019

Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32.

1 reference

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Effect of protease inhibitors and substrates on deoxycorticosterone binding to its receptor in dog MDCK kidney cells

1 reference

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7 January 2021

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The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

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Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

1 reference

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Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

1 reference

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Inactivation of Bcl-2 by phosphorylation

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Serum withdrawal and etoposide induce apoptosis in human lung carcinoma cell line A549 via distinct pathways.

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Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells

1 reference

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Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

1 reference

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7 January 2021

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Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death

1 reference

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7 January 2021

based on heuristic

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Activation of Raf by ionizing radiation

1 reference

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7 January 2021

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Regulators of cell death

1 reference

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7 January 2021

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Raf-1 activates MAP kinase-kinase

1 reference

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Nuclear serine protease activity contributes to bile acid-induced apoptosis in hepatocytes

1 reference

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7 January 2021

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

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Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents

1 reference

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Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin

1 reference

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Protease activation during apoptosis: death by a thousand cuts?

1 reference

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Apoptosis: alive and kicking in 1997

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Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

1 reference

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7 January 2021

based on heuristic

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Negative regulation of Raf-1 by phosphorylation of serine 621.

1 reference

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7 January 2021

based on heuristic

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The complexity of Raf-1 regulation

1 reference

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7 January 2021

based on heuristic

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202685

7 January 2021

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202685

7 January 2021

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A novel serine esterase expressed by cytotoxic T lymphocytes

1 reference

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7 January 2021

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Paclitaxel (taxol)

1 reference

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7 January 2021

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Caspases: Intracellular Signaling by Proteolysis

1 reference

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7 January 2021

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Paclitaxel-induced apoptosis in MCF-7 breast-cancer cells

1 reference

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Promotion of microtubule assembly in vitro by taxol

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Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation.

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7-Hydroxystaurosporine (UCN-01) Induces Apoptosis in Human Colon Carcinoma and Leukemia Cells Independently of p53

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Camptothecin-induced apoptosis in p53-null human leukemia HL60 cells and their isolated nuclei: effects of the protease inhibitors Z-VAD-fmk and dichloroisocoumarin suggest an involvement of both caspases and serine proteases

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Mitogen-activated protein kinase cascades and regulation of gene expression

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ICE-related proteases in apoptosis.

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

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Irreversible inhibition of trypsin by TLCK. A continuous method for kinetic study of irreversible enzymatic inhibitors in the presence of substrate.

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Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

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Cellular events in Fas/APO-1-mediated apoptosis in JURKAT T lymphocytes

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Life, death, and the pursuit of apoptosis.

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Taxol induces tyrosine phosphorylation of Shc and its association with Grb2 in murine RAW 264.7 cells

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Activation of CPP32-like Proteases Is Not Sufficient to Trigger Apoptosis: Inhibition of Apoptosis by Agents that Suppress Activation of AP24, but Not CPP32-like Activity

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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Target protease specificity of the viral serpin CrmA. Analysis of five caspases

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