Exploiting the Therapeutic Potential of Endogenous Immunomodulatory Systems in Multiple Sclerosis-Special Focus on the Peroxisome Proliferator-Activated Receptors (PPARs) and the Kynurenines (Q61812962)

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scientific article published on 19 January 2019

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English	Exploiting the Therapeutic Potential of Endogenous Immunomodulatory Systems in Multiple Sclerosis-Special Focus on the Peroxisome Proliferator-Activated Receptors (PPARs) and the Kynurenines	scientific article published on 19 January 2019

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scholarly article

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20 April 2020

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Exploiting the Therapeutic Potential of Endogenous Immunomodulatory Systems in Multiple Sclerosis-Special Focus on the Peroxisome Proliferator-Activated Receptors (PPARs) and the Kynurenines (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30669473%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

peroxisome proliferator-activated receptor

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multiple sclerosis

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30 June 2019

25 June 2019

19 November 2019

21 December 2019

22 December 2019

1 reference

19 November 2019

intracellular receptor

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21 December 2019

transcription factor

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22 December 2019

author name string

Bernadett Fakan

1

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20 April 2020

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19 January 2019

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19 November 2019

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20 April 2020

International Journal of Molecular Sciences

6 references

30 June 2019

25 June 2019

19 November 2019

21 December 2019

22 December 2019

Europe PubMed Central

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20 April 2020

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Europe PubMed Central

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20 April 2020

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Europe PubMed Central

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copyright license

Creative Commons Attribution

5 references

30 June 2019

25 June 2019

19 November 2019

21 December 2019

22 December 2019

copyright status

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on focus list of Wikimedia project

0 references

Plasma and cerebrospinal fluid tryptophan in multiple sclerosis and degenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of reactive oxygen species in the pathogenesis of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone)

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased plasma serotonin in primary pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxin quinolinic acid is selectively elevated in spinal cords of rats with experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2, soluble interleukin-2-receptor, neopterin,l-tryptophan and ?2-microglobulin levels in CSF and serum of patients with relapsing-remitting or chronic-progressive multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum tryptophan, kynurenine, and neopterin in patients with Guillain-Barre-syndrome (GBS) and multiple sclerosis (MS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3‐Hydroxykynurenine, an Endogenous Oxidative Stress Generator, Causes Neuronal Cell Death with Apoptotic Features and Region Selectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Member of the peroxisome proliferator-activated receptor family of transcription factors is differentially expressed by oligodendrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Th1 and Th2 cells in autoimmune demyelinating disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 plays a crucial role in the induction phase of myelin oligodendrocyte glucoprotein 35-55 induced experimental autoimmune encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFN-gamma inhibits presentation of a tumor/self peptide by CD8 alpha- dendritic cells via potentiation of the CD8 alpha+ subset

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate excitotoxicity--a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival activity of troglitazone in rat motoneurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of macrophage gene expression by the peroxisome proliferator-activated receptor-gamma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cytokine expression by ligands of peroxisome proliferator activated receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-12 production, IL-12 signaling and Th1 differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell apoptosis by tryptophan catabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased level of kynurenic acid in cerebrospinal fluid of relapsing-onset multiple sclerosis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging roles of PPARs in inflammation and immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNFalpha downregulates PPARdelta expression in oligodendrocyte progenitor cells: implications for demyelinating diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glial cell proinflammatory activities by peroxisome proliferator-activated receptor gamma agonist confers partial protection during antimyelin oligodendrocyte glycoprotein demyelination in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR γ activators induce growth arrest and process extension in B12 oligodendrocyte‐like cells and terminal differentiation of cultured oligodendrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of PPARdelta in murine central nervous system: expression in oligodendrocytes and neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-gamma-deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic potential of IFN-gamma-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor alpha agonists as therapy for autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IDO (indolamine 2,3-dioxygenase) expression and function in the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell apoptosis by kynurenines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of pioglitazone treatment in a patient with secondary multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-specific T cell functions are suppressed over the estrogen-dendritic cell-indoleamine 2,3-dioxygenase axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenine metabolism in multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-beta affects the tryptophan metabolism in multiple sclerosis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARgamma antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome-proliferator-activated receptor-gamma (PPARgamma) activation protects neurons from NMDA excitotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear receptors and autoimmune disease: the potential of PPAR agonists to treat multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple sclerosis--the plaque and its pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor alpha, delta, gamma1 and gamma2 expressions are present in human monocyte-derived dendritic cells and modulate dendritic cell maturation by addition of subtype-specific ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-alpha and retinoid X receptor agonists inhibit inflammatory responses of astrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARgamma antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-deoxy-Delta12,14-prostaglandin J2

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor gamma control of dendritic cell function contributes to development of CD4+ T cell anergy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytic activation in relation to inflammatory markers during clinical exacerbation of relapsing-remitting multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IDO expression in the brain: a double-edged sword

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of peroxisome proliferator-activated receptor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 activation confers neuroprotection in experimental optic neuritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain endothelial PPARgamma controls inflammation-induced CD4+ T cell adhesion and transmigration in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-alpha agonist fenofibrate regulates IL-12 family cytokine expression in the CNS: relevance to multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO) on primary human CD4+ and CD8+ T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synthetic peroxisome proliferator-activated receptor-gamma agonist ciglitazone attenuates neuroinflammation and accelerates encapsulation in bacterial brain abscesses

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of the PPARgamma gene polymorphism Pro12Ala with delayed onset of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting PPAR as a therapy to treat multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17+IL-10+ T cells, CD4(-) IFN-gamma+ cells, and decreased macrophage IL-6 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant regulatory mechanisms in neutrophils and lymphocytes after intense exercise.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional modulation of the immune response by peroxisome proliferator-activated receptor-{alpha} agonists in autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of T-cell response and prolongation of allograft survival in a rat model by tryptophan catabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pilot test of pioglitazone as an add-on in patients with relapsing remitting multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unlike PPARγ, PPARα or PPARβ/δ activation does not promote human monocyte differentiation toward alternative macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-gamma agonists promote differentiation and antioxidant defenses of oligodendrocyte progenitor cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes: biology and pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of pioglitazone on diffusion tensor imaging indices in multiple sclerosis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6: regulator of Treg/Th17 balance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eicosapentaenoic Acid Disrupts the Balance Between Tregs and IL-17+ T Cells Through PPARγ Nuclear Receptor Activation and Protects Cardiac Allografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral resveratrol reduces neuronal damage in a model of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARδ deficient mice develop elevated Th1/Th17 responses and prolonged experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes in the tempest of multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kynurenine system and immunoregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of omega-3 Fatty acids on matrix metalloproteinase-9 production and cell migration in human immune cells: implications for multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding the roles of the kynurenine pathway in multiple sclerosis progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of PGC-1α expression can be detected in blood samples of patients with ST-segment elevation acute myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biology and therapeutic applications of peroxisome proliferator- activated receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial disturbances, tryptophan metabolites and neurodegeneration: medicinal chemistry aspects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aryl hydrocarbon receptor ligand effects in RBL2H3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ω-3 fatty acid treatment in multiple sclerosis (OFAMS Study): a randomized, double-blind, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemfibrozil, a lipid lowering drug, inhibits the activation of primary human microglia via peroxisome proliferator-activated receptor β.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of engineered bone marrow stem cells to deliver brain derived neurotrophic factor under the control of a tetracycline sensitive response element in experimental allergic encephalomyelitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple sclerosis: the role of cytokines in pathogenesis and in therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenines in the CNS: recent advances and new questions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology of partial PGC-1α deficiency recapitulates features of mitochondrial encephalopathies but not of neurodegenerative diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

α-Lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pro-inflammatory cytokines negatively regulate PPARγ mediated gene expression in both human and murine macrophages via multiple mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated levels of PPAR-gamma in the cerebrospinal fluid of patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol exacerbates both autoimmune and viral models of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myelin alters the inflammatory phenotype of macrophages by activating PPARs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative modification of blood serum proteins in multiple sclerosis after interferon or mitoxantrone treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 is decreased during relapses in patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress the Th17 response in allergic rhinitis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiinflammatory activity of glucomoringin isothiocyanate in a mouse model of experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Teriflunomide - a new oral agent for multiple sclerosis treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining a role for laquinimod in multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endogenous α7 nicotinic acetylcholine receptor antagonist kynurenic acid modulates amyloid-β-induced inflammation in BV-2 microglial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosiglitazone, but not epigallocatechin-3-gallate, attenuates the decrease in PGC-1α protein levels in palmitate-induced insulin-resistant C2C12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SIRT1 deacetylates RORγt and enhances Th17 cell generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple Sclerosis and T Lymphocytes: An Entangled Story

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling in dendritic cells: its role in regulation of immunity and tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indoleamine 2,3 Dioxygenase (IDO) Expression and Activity in Relapsing-Remitting Multiple Sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in multiple sclerosis: Central and peripheral mode of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathological comparison of Kearns-Sayre syndrome and PGC-1α-deficient mice suggests a novel concept for vacuole formation in mitochondrial encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of PPAR isotypes in the adult mouse and human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of age-related clinical progression in PGC-1α-deficient mice - implications for mitochondrial encephalopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol defends blood-brain barrier integrity in experimental autoimmune encephalomyelitis mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immunomodulatory effect of laquinimod in CNS autoimmunity is mediated by the aryl hydrocarbon receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From Leflunomide to Teriflunomide: Drug Development and Immunosuppressive Oral Drugs in the Treatment of Multiple Sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenic acid downregulates IL-17/1L-23 axis in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unlike PPARgamma, neither other PPARs nor PGC-1alpha is elevated in the cerebrospinal fluid of patients with multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR-γ promotes type 2 immune responses in allergy and nematode infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions Between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma on Neuroinflammation, Demyelination, and Remyelination in Multiple Sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-motor Behavioral Alterations of PGC-1α-Deficient Mice - A Peculiar Phenotype With Slight Male Preponderance and No Apparent Progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30669473

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/IJMS20020426

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30669473%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30669473%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30669473%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

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