Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology (Q61651710)

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scientific article published on 01 August 2018

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English	Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology	scientific article published on 01 August 2018

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31 March 2020

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5 July 2021

18 October 2022

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology (English)

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31 March 2020

hypertrophic cardiomyopathy

3 references

6 October 2019

10 October 2019

11 October 2019

human musculoskeletal system

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6 October 2019

circulatory system

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10 October 2019

1 reference

11 October 2019

energy metabolism

1 reference

5 July 2021

Jolanda van der Velden

1

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Inês Falcão-Pires

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Denise Hilfiker-Kleiner

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Denise Hilfiker-Kleiner

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Gilda Varricchi

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Gilda Varricchi

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Carlo G Tocchetti

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Anna Bianco

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Vasco Sequeira

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Nazha Hamdani

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Adelino F Leite-Moreira

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Thomas Thum

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Jean-Luc Balligand

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Stephane Heymans

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1 August 2018

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31 March 2020

5 July 2021

18 October 2022

Cardiovascular Research

6 references

6 October 2019

10 October 2019

11 October 2019

Europe PubMed Central

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31 March 2020

5 July 2021

18 October 2022

114

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1273-1280

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31 March 2020

copyright license

Creative Commons Attribution-NonCommercial 4.0 International

5 references

Europe PubMed Central

6 October 2019

Europe PubMed Central

10 October 2019

Europe PubMed Central

11 October 2019

Europe PubMed Central

5 July 2021

Europe PubMed Central

18 October 2022

A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of MgADP in the development of diastolic dysfunction in the intact beating rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure to Maintain a Low ADP Concentration Impairs Diastolic Function in Hypertrophied Rat Hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Mutant Tropomyosin That Causes Hypertrophic Cardiomyopathy Is Expressed In Vivo and Associated With an Increased Calcium Sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic stretch induces the release of growth promoting factors from cultured neonatal cardiomyocytes and cardiac fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of myocardial myocyte enhancer factor 2C and myocyte enhancer factor 2C-regulated gene expression in diabetic patients with nonischemic heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stretch-induced paracrine hypertrophic stimuli increase TGF-beta1 expression in cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac energy metabolism homeostasis: role of cytosolic calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the Euro

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in tension-dependent ATP consumption induced by cardiac troponin T mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: new insights from multiparametric magnetic resonance imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

R-92L and R-92W mutations in cardiac troponin T lead to distinct energetic phenotypes in intact mouse hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Randle cycle revisited: a new head for an old hat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulating fatty acid oxidation in heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microvascular Function Is Selectively Impaired in Patients With Hypertrophic Cardiomyopathy and Sarcomere Myofilament Gene Mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The coronary circulation and blood flow in left ventricular hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carriers of the hypertrophic cardiomyopathy MYBPC3 mutation are characterized by reduced myocardial efficiency in the absence of hypertrophy and microvascular dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophic cardiomyopathy: translating cellular cross talk into therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic role of CMR in patients presenting with ventricular arrhythmias

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exercise capacity and paroxysmal atrial fibrillation in patients with hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coronary microvascular ischemia in hypertrophic cardiomyopathy - a pixel-wise quantitative cardiovascular magnetic resonance perfusion study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of human brown adipose tissue by a β3-adrenergic receptor agonist.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining phenotypes and disease progression in sarcomeric cardiomyopathies: contemporary role of clinical investigations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic advances in sarcomeric cardiomyopathies: state of the art.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial efficiency is an important determinant of functional improvement after aortic valve replacement in aortic valve stenosis patients: a combined PET and CMR study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New perspectives on the prevalence of hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiopulmonary responses and prognosis in hypertrophic cardiomyopathy: a potential role for comprehensive noninvasive hemodynamic assessment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Left ventricular outflow tract gradient is associated with reduced capillary density in hypertrophic cardiomyopathy irrespective of genotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Revisiting Cardiac Cellular Composition

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of Genotype on the Occurrence of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pleiotropic mechanisms of action of perhexiline in heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic Modulation by Medium-Chain Triglycerides Reduces Oxidative Stress and Ameliorates CD36-Mediated Cardiac Remodeling in Spontaneously Hypertensive Rat in the Initial and Established Stages of Hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of Myocardial Ischemia in Hypertrophic Cardiomyopathy: Insights From Wave Intensity Analysis and Magnetic Resonance

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic support for the heart: complementary therapy for heart failure?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic cardiomyopathies - fighting the next epidemic

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disease Stage-Dependent Changes in Cardiac Contractile Performance and Oxygen Utilization Underlie Reduced Myocardial Efficiency in Human Inherited Hypertrophic Cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex Energy Metabolic Changes in Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac myocyte β3-adrenergic receptors prevent myocardial fibrosis by modulating oxidant stress-dependent paracrine signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29912308

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/CVR/CVY147

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29912308%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29912308%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29912308%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

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