Myeloma bone disease (Q60482582)

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Language	Label	Description	Also known as
English	Myeloma bone disease	No description defined

Statements

instance of

scholarly article

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review article

4 references

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PubMed Central

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13 March 2019

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PubMed

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22 March 2019

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PubMed

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3 April 2019

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PubMed

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17 June 2019

title

Myeloma bone disease (English)

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main subject

bone disease

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PubMed Central

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13 March 2019

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PubMed

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22 March 2019

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PubMed

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3 April 2019

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PubMed

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17 June 2019

multiple myeloma

4 references

stated in

PubMed Central

retrieved

13 March 2019

stated in

PubMed

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22 March 2019

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PubMed

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3 April 2019

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PubMed

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17 June 2019

author name string

Ralph D Sanderson

series ordinal

1

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Joshua Epstein

series ordinal

2

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language of work or name

English

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publication date

November 2009

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1 November 2009

4 references

stated in

PubMed Central

retrieved

13 March 2019

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PubMed Central

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22 March 2019

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PubMed Central

retrieved

3 April 2019

stated in

PubMed Central

retrieved

17 June 2019

published in

Journal of Bone and Mineral Research

4 references

stated in

PubMed Central

retrieved

13 March 2019

stated in

PubMed Central

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22 March 2019

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PubMed Central

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3 April 2019

stated in

PubMed Central

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17 June 2019

volume

24

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issue

11

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page(s)

1783-8

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copyright license

Creative Commons Attribution 2.5 Generic

4 references

stated in

Europe PubMed Central

retrieved

13 March 2019

stated in

Europe PubMed Central

retrieved

22 March 2019

stated in

Europe PubMed Central

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3 April 2019

stated in

Europe PubMed Central

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17 June 2019

on focus list of Wikimedia project

ScienceSource

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cites work

Osteoclast-like cell formation by circulating myeloma B lymphocytes: role of RANK-L.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential analysis of biochemical markers of bone resorption and bone densitometry in multiple myeloma

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

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inferred from PubMed ID database lookup

Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblast pathway of osteoclast stimulation.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

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Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

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Wnt signaling in osteoblasts and bone diseases

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

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Direct bone resorbing activity of murine myeloma cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

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Computed tomography in diagnosis and management of multiple myeloma and its variants

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a useful prognostic indicator in multiple myeloma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

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Development of an in vivo model of human multiple myeloma bone disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

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Biochemical bone markers in patients with multiple myeloma.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High serum bone-specific alkaline phosphatase level after bortezomib-combined therapy in refractory multiple myeloma: possible role of bortezomib on osteoblast differentiation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

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Functional osteoclast-like transformation of cultured human myeloma cell lines.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

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A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

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Myeloma and bone disease: "the dangerous tango".

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-?B ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership?

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between serum levels of vascular endothelial growth factor, hepatocyte growth factor and matrix metalloproteinase-9 with biochemical markers of bone disease in multiple myeloma

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnetic resonance imaging in multiple myeloma: diagnostic and clinical implications

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum levels of OPG, RANKL and RANKL/OPG ratio in newly-diagnosed patients with multiple myeloma. Clinical correlations

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathologic fractures correlate with reduced survival in patients with malignant bone disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathogenesis of the bone disease of multiple myeloma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporation of the bone marker carboxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical markers of bone disease in asymptomatic early stage multiple myeloma. A study on their role in identifying high risk patients

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidetector CT of the spine in multiple myeloma: comparison with MR imaging and radiography

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha(v)beta(3) integrin engagement enhances cell invasiveness in human multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone resorption parameters [carboxy-terminal telopeptide of type-I collagen (ICTP), amino-terminal collagen type-I telopeptide (NTx), and deoxypyridinoline (Dpd)] in MGUS and multiple myeloma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review of 1027 patients with newly diagnosed multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of five biochemical markers of bone resorption in multiple myeloma: elevated pre-treatment levels of S-ICTP and U-Ntx are predictive for early progression of the bone disease during standard chemotherapy.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of receptor activator of nuclear factor kappaB ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profiling of multiple myeloma reveals molecular portraits in relation to the pathogenesis of the disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) correlate with the extent of bone disease and survival in patients with multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New Insights in Myeloma-induced Osteolysis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High heparanase activity in multiple myeloma is associated with elevated microvessel density

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fracture risk in monoclonal gammopathy of undetermined significance

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1alpha and MIP-1beta correlates with lytic bone lesions in patients with multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteasome inhibitor, bortezomib suppresses primary myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of myeloma bone disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bortezomib induces osteoblast differentiation via Wnt-independent activation of beta-catenin/TCF signaling

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta(3) Integrin subunit mediates the bone-resorbing function exerted by cultured myeloma plasma cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/19839769

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1359/JBMR.090901

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PMC publication ID

3276340

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PubMed publication ID

19839769

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