SMAD family member 2 (Q6917574)

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mammalian protein found in Homo sapiens
  • MAD homolog 2
  • SMAD2
  • JV18-1
  • SMAD, mothers against DPP homolog 2
  • hMAD-2
  • Mad-related protein 2
  • mother against DPP homolog 2
  • SMAD 2
  • hSMAD2
  • mothers against decapentaplegic homolog 2
  • Sma- and Mad-related protein 2
edit
Language Label Description Also known as
English
SMAD family member 2
mammalian protein found in Homo sapiens
  • MAD homolog 2
  • SMAD2
  • JV18-1
  • SMAD, mothers against DPP homolog 2
  • hMAD-2
  • Mad-related protein 2
  • mother against DPP homolog 2
  • SMAD 2
  • hSMAD2
  • mothers against decapentaplegic homolog 2
  • Sma- and Mad-related protein 2

Statements

instance of
R-SMAD
0 references
subclass of
SMAD protein
0 references
molecular function
protein binding
determination method or standard
IPI
49 references
retrieved
8 April 2019
stated in
Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
C18 ORF1, a novel negative regulator of transforming growth factor-β signaling
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-β signal molecule Smad2
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Roles of pathway-specific and inhibitory Smads in activin receptor signaling
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
USP15 is a deubiquitylating enzyme for receptor-activated SMADs
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional proteomics mapping of a human signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Pin1/mutant p53 axis promotes aggressiveness in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
TIF1gamma controls erythroid cell fate by regulating transcription elongation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene, SMAD7, via HDAC3 and PRMT5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of human FAST-1, a TGF beta and activin signal transducer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Intercellular variation in signaling through the TGF-β pathway and its relation to cell density and cell cycle phase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of heteromeric smad protein assembly in TGF-beta signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IPI
cell component
nucleus
determination method or standard
IDA
IEA
9 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IEA
retrieved
8 April 2019
stated in
ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-β signal molecule Smad2
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cellular response to hypoxia involves signaling via Smad proteins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
biological process
transforming growth factor beta receptor signaling pathway
determination method or standard
IDA
TAS
IMP
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
TAS
retrieved
8 April 2019
stated in
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IEA
retrieved
8 April 2019
stated in
SMAD proteins control DROSHA-mediated microRNA maturation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
positive regulation of transcription, DNA-templated
determination method or standard
IDA
ISS
IEA
IMP
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q15796
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
ISS
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
ISS
retrieved
8 April 2019
stated in
Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IEA
retrieved
8 April 2019
stated in
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
retrieved
8 April 2019
stated in
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15796
determination method or standard
IDA
Gene Atlas image
PBB GE SMAD2 203075 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D051899
subject named as
Smad2 Protein
0 references
 
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