NPC intracellular cholesterol transporter 1 (Q6748237)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15118

NPC1:NPC2

1 reference

Transporter Classification Database ID

2.A.6.6.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

Niemann-Pick C1, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Sterol-sensing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

virus receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

lipid transporter activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

sterol transporter activity

1 reference

8 April 2019

Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

cholesterol binding

1 reference

8 April 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

protein binding

4 references

8 April 2019

Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

Identification of cholesterol-regulating genes by targeted RNAi screening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

The Niemann-Pick C1 and caveolin-1 proteins interact to modulate efflux of low density lipoprotein-derived cholesterol from late endocytic compartments

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

transmembrane signaling receptor activity

1 reference

8 April 2019

Mutations in NPC1 highlight a conserved NPC1-specific cysteine-rich domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

signaling receptor activity

1 reference

8 April 2019

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

integral component of membrane

cell component

3 references

vesicle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

Golgi apparatus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118

3 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118

26 September 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118

late endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

integral component of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

endoplasmic reticulum

1 reference

8 April 2019

Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann-Pick type C disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

perinuclear region of cytoplasm

1 reference

8 April 2019

Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann-Pick type C disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

membrane raft

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

lysosome

Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

extracellular exosome

1 reference

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118

lysosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118

26 September 2017

26 September 2017

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118

lysosomal membrane

3 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

HDA

extracellular exosome

HDA

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

integral component of lysosomal membrane

HDA

cellular response to steroid hormone stimulus

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

response to cadmium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

endocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

negative regulation of macroautophagy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

bile acid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

cholesterol transport

1 reference

8 April 2019

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

establishment of protein localization to membrane

1 reference

8 April 2019

Interaction of AnxA6 with isolated and artificial lipid microdomains; importance of lipid composition and calcium content

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

cellular response to low-density lipoprotein particle stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

cholesterol metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

negative regulation of cell death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

autophagy

IGI

1 reference

8 April 2019

Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

membrane raft organization

IGI

1 reference

8 April 2019

Interaction of AnxA6 with isolated and artificial lipid microdomains; importance of lipid composition and calcium content

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

lysosomal transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

viral entry into host cell

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

3 references

8 April 2019

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

cholesterol homeostasis

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

adult walking behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

signal transduction

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15118&geneProductId=UniProtKB:O15118

low-density lipoprotein particle clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

1 reference

8 April 2019

intracellular cholesterol transport

3 references

8 April 2019

3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

cholesterol homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

6 references

8 April 2019

8 April 2019

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

3.3 Å structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

8 April 2019

NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15118

Gene Atlas image

PBB GE NPC1 202679 at fs.png
732 × 530; 11 KB

0 references

has part(s)

Sterol-sensing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15118

Niemann-Pick C1, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15118

Commons category

NPC1

1 reference

imported from Wikimedia project

Catalan Wikipedia

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

Transporter Classification Database ID

English

2.A.6.6.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database