Withaferin A (Q6606395)

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chemical compound
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Language Label Description Also known as
English
Withaferin A
chemical compound

    Statements

    subclass of
    Withanolides
    0 references
    chemical structure
    Withaferin A.svg
    1,535 × 1,300; 35 KB
    0 references
    mass
    470.266838936 dalton
    1 reference
    based on heuristic
    inferred from SMILES
    chemical formula
    C₂₈H₃₈O₆
    1 reference
    stated in
    PubChem
    canonical SMILES
    O=C1OC(CC(=C1CO)C)C(C)C2CCC3C4CC5OC65C(O)C=CC(=O)C6(C)C4CCC23C
    0 references
    isomeric SMILES
    O=C/1O[C@H](CC(=C\1CO)\C)[C@@H](C)[C@H]6CC[C@@H]4[C@]6(C)CC[C@@H]3[C@]5(C(=O)\C=C/[C@H](O)[C@]52O[C@@H]2C[C@H]34)C
    1 reference
    imported from Wikimedia project
    English Wikipedia
    found in taxon
    Withania somnifera
    34 references
    stated in
    Distribution of the chemotypes ofWithania somnifera in some areas of Israel: Feeding studies withSpodoptera littoralis larvae and chemical examination of withanolide content
    stated in
    Effects of glycowithanolides fromWithania somnifera on morphine-induced inhibition of intestinal motility and tolerance to analgesia in mice
    stated in
    Cholinesterase inhibiting withanolides from Withania somnifera
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    A New Withanolide from the Roots of Withania somnifera
    stated in
    Anti-stress activity of sitoindosides VII and VIII, new acylsterylglucosides fromWithania somnifera
    stated in
    Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves
    stated in
    A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice.
    stated in
    Cyclooxygenase-2 enzyme inhibitory withanolides from Withania somnifera leaves
    stated in
    Withanolide synthesis in cultures of Withania somnifera transformed with Agrobacterium tumefaciens
    stated in
    Quantitative HPLC analysis of withanolides in Withania somnifera
    stated in
    Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum
    stated in
    In vitro propagation of Withania somnifera and isolation of withanolides with immunosuppressive activity
    stated in
    Production of withaferin A in shoot cultures of Withania somnifera.
    stated in
    Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia
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    Effect of Withaferin A on the development and decay of thermotolerance in B16F1 melanoma: a preliminary study
    stated in
    Cell Differentiation Inducing Steroids from Withania somnifera L. (DUN.).
    stated in
    Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities.
    stated in
    Modification of bone marrow radiosensensitivity by medicinal plant extracts
    stated in
    Cholinesterase Inhibiting Withanolides from Withania somnifera.
    stated in
    2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera
    stated in
    Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells
    stated in
    Chlorinated and diepoxy withanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line
    stated in
    Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation.
    stated in
    Comprehensive metabolic fingerprinting of Withania somnifera leaf and root extracts
    stated in
    Chlorinated and diepoxy withanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line
    stated in
    Phytochemical and genetic analysis in selected chemotypes of Withania somnifera
    stated in
    In vitro propagation of Withania somnifera and isolation of withanolides with immunosuppressive activity
    stated in
    Cyclooxygenase-2 enzyme inhibitory withanolides from Withania somnifera leaves
    stated in
    Cell Differentiation Inducing Steroids from Withania somnifera L. (DUN.).
    stated in
    Unusually sulfated and oxygenated steroids from Withania somnifera.
    stated in
    Withanolides from Withania somnifera roots
    stated in
    Unusual withanolides from aeroponically grown Withania somnifera
    stated in
    Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities.
    stated in
    Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells

    Identifiers

    NSC number
    101088
    0 references
    273757
    0 references
    KNApSAcK ID
    C00003676
    0 references
    KEGG ID
    C08841
    0 references
    Freebase ID
    /m/0h637nd
    0 references
     
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