Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase. (Q64986365)

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19 March 2020

title

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase (English)

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19 March 2020

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19 March 2020

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19 March 2020

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19 March 2020

Gergely L Lukacs

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19 March 2020

Ryohei Sakai

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19 March 2020

Misaki Aki

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19 March 2020

Takeshi Fujihara

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19 March 2020

Momoko Higashi

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19 March 2020

Seiko Susuki-Miyata

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19 March 2020

Masanori Miyata

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19 March 2020

Norihito Fukuda

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19 March 2020

Akihiko Yoshida

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19 March 2020

Haijin Xu

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19 March 2020

publication date

1 March 2018

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19 March 2020

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19 March 2020

volume

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issue

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19 March 2020

page(s)

694-708.e7

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Cystic fibrosis: molecular biology and therapeutic implications

19 March 2020

cites work

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The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

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A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes

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Visualization of retroviral replication in living cells reveals budding into multivesicular bodies.

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Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes

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Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth

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The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.

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Degradation-mediated protein quality control in the nucleus

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Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomes

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The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells

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A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking

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Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells

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Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

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Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel

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Plasticity of polyubiquitin recognition as lysosomal targeting signals by the endosomal sorting machinery

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Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones

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Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.

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CFTR function and prospects for therapy

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Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

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Analysis of endocytic trafficking by single-cell fluorescence ratio imaging

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CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha.

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N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic

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The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells

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K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway

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Mechanisms for rescue of correctable folding defects in CFTRDelta F508.

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Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding

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BIN1 localizes the L-type calcium channel to cardiac T-tubules

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c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells

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Peripheral protein quality control removes unfolded CFTR from the plasma membrane

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A molecular network for de novo generation of the apical surface and lumen

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Quality control for unfolded proteins at the plasma membrane

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An Improved Bimolecular Fluorescence Complementation Assay with a High Signal-To-Noise Ratio

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Ubiquitin: Same Molecule, Different Degradation Pathways

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Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates.

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12 December 2020

Protein quality control at the plasma membrane

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12 December 2020

Use of primary cultures of human bronchial epithelial cells isolated from cystic fibrosis patients for the pre-clinical testing of CFTR modulators

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A public genome-scale lentiviral expression library of human ORFs

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12 December 2020

Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity

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12 December 2020

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

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12 December 2020

Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator

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12 December 2020

Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function

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Mitochondrial quality control: an integrated network of pathways

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12 December 2020

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

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Use of kinase inhibitors to correct ΔF508-CFTR function

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Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

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Cleaning up: ER-associated degradation to the rescue

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The ribosome as a hub for protein quality control

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Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor.

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The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

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Mechanism-based corrector combination restores ΔF508-CFTR folding and function

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Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6

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12 December 2020

Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation

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12 December 2020

Lysine 63-linked polyubiquitination is required for EGF receptor degradation

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12 December 2020

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

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12 December 2020

Different Raf protein kinases mediate different signaling pathways to stimulate E3 ligase RFFL gene expression in cell migration regulation

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12 December 2020

Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane

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12 December 2020

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

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12 December 2020

Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis

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Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

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12 December 2020

RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR.

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12 December 2020

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∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis

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Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases

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SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation

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Mutation-specific downregulation of CFTR2 variants by gating potentiators

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12 December 2020

10.1016/J.DEVCEL.2018.02.001

Identifiers

DOI

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19 March 2020

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19 March 2020

PubMed publication ID

29503157

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