MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. (Q64947029)

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scientific article published on 31 May 2018

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English	MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.	scientific article published on 31 May 2018

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MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. (English)

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Sarah J Wu

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Paul A Northcott

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Paul A Northcott

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Ali Shilatifard

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Shilpa S Dhar

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Dongyu Zhao

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Tao Lin

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Bingnan Gu

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Kyuson Yun

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Vidya Gopalakrishnan

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Elsa R Flores

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Veena Rajaram

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Wei Li

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Roy V Sillitoe

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Kaifu Chen

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Min Gyu Lee

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publication date

31 May 2018

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published in

Molecular Cell

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70

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5

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825-841.e6

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A BCL6/BCOR/SIRT1 complex triggers neurogenesis and suppresses medulloblastoma by repressing Sonic Hedgehog signaling

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Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes

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The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

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Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.

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Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma

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MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis

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Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation

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A tumor suppressor role for C/EBPα in solid tumors: more than fat and blood

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Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions.

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A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription.

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12 December 2020

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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

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Identifiers

DOI

10.1016/J.MOLCEL.2018.04.028

1 reference

stated in

Europe PubMed Central

PMC publication ID

6528658

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6528658

PMC publication ID

6528658

1 reference

stated in

Europe PubMed Central

PMC publication ID

6528658

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6528658

PubMed publication ID

29861161

1 reference

stated in

Europe PubMed Central

PMC publication ID

6528658

retrieved

1 July 2019

reference URL

http://europepmc.org/abstract/PMC/6528658

 

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