Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis (Q64272039)

12 December 2020

The blood-brain barrier and cerebral microcirculation in Alzheimer disease

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12 December 2020

Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload

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12 December 2020

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

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12 December 2020

Cathepsin D. Purification of isoenzymes from human and chicken liver

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12 December 2020

Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells. Requirements for homology for receptor binding activity

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12 December 2020

Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

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12 December 2020

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

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12 December 2020

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

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12 December 2020

Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-beta by cathepsin D.

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Apolipoprotein B mRNA editing in 12 different mammalian species: hepatic expression is reflected in low concentrations of apoB-containing plasma lipoproteins

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12 December 2020

Effect of alkalizing agents on the processing of the beta-amyloid precursor protein.

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12 December 2020

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.

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12 December 2020

Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein

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12 December 2020

Chloroquine administration in mice increases beta-amyloid immunoreactivity and attenuates kainate-induced blood-brain barrier dysfunction

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12 December 2020

Increased Neuronal Endocytosis and Protease Delivery to Early Endosomes in Sporadic Alzheimer’s Disease: Neuropathologic Evidence for a Mechanism of Increased β-Amyloidogenesis

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12 December 2020

Serum protein leakage in Alzheimer's disease revisited

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12 December 2020

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

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12 December 2020

Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

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12 December 2020

Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels

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12 December 2020

The apolipoprotein E content of HDL in cerebrospinal fluid is higher in children than in adults

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12 December 2020

The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease

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12 December 2020

Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo. Evidence for retroendocytosis

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12 December 2020

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

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12 December 2020

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

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12 December 2020

Characterization of four lipoprotein classes in human cerebrospinal fluid

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12 December 2020

Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease

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12 December 2020

Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalization.

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12 December 2020

Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration

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12 December 2020

Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model

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12 December 2020

Brain cholesterol: long secret life behind a barrier.

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12 December 2020

Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation.

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12 December 2020

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

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12 December 2020

BACE is degraded via the lysosomal pathway

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12 December 2020

Microvascular injury and blood-brain barrier leakage in Alzheimer's disease

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12 December 2020

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12 December 2020

Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease

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12 December 2020

Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Abeta fibrillogenesis in Alzheimer's disease

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12 December 2020

Effects of cellular cholesterol loading on macrophage foam cell lysosome acidification

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12 December 2020

Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies

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12 December 2020

Beyond amyloid: the next generation of Alzheimer's disease therapeutics.

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12 December 2020

Autophagy, amyloidogenesis and Alzheimer disease

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12 December 2020

Crystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein Production

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12 December 2020

Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease

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12 December 2020

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

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12 December 2020

Overexpression of human apolipoprotein B-100 induces severe neurodegeneration in transgenic mice

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12 December 2020

Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization

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12 December 2020

Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

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12 December 2020

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats.

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12 December 2020

Three-dimensional colocalization analysis of plasma-derived apolipoprotein B with amyloid plaques in APP/PS1 transgenic mice

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12 December 2020

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

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12 December 2020

Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later

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12 December 2020

Apolipoprotein E and cholesterol in aging and disease in the brain

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12 December 2020

Differential effects of dietary fatty acids on the cerebral distribution of plasma-derived apo B lipoproteins with amyloid-beta

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12 December 2020

The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat.

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12 December 2020

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

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12 December 2020

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

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12 December 2020

Endolysosome Mechanisms Associated with Alzheimer's Disease-like Pathology in Rabbits Ingesting Cholesterol-Enriched Diet

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12 December 2020

Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease

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12 December 2020

A genome-wide enhancer screen implicates sphingolipid composition in vacuolar ATPase function in Saccharomyces cerevisiae.

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12 December 2020

Cholesterol and LDL relate to neuritic plaques and to APOE4 presence but not to neurofibrillary tangles

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12 December 2020

Epidemiology of Alzheimer disease

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12 December 2020

Alzheimer's disease: the challenge of the second century

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12 December 2020

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

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12 December 2020

The projected effect of risk factor reduction on Alzheimer's disease prevalence

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12 December 2020

Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study

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12 December 2020

Vascular changes in rat hippocampus following a high saturated fat and cholesterol diet

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12 December 2020

Twenty years of Alzheimer's disease-causing mutations

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12 December 2020

Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E.

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12 December 2020

Membrane trafficking pathways in Alzheimer's disease

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12 December 2020

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

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12 December 2020

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody.

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12 December 2020

High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease.

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12 December 2020

Endolysosome involvement in LDL cholesterol-induced Alzheimer's disease-like pathology in primary cultured neurons

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12 December 2020

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

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12 December 2020

The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood-brain barrier integrity differ for diet-induced obese and diet-resistant rats

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12 December 2020

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

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12 December 2020

Midlife vascular risk factors and their association with dementia deaths: results from a Norwegian prospective study followed up for 35 years

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12 December 2020

Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies

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12 December 2020

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

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12 December 2020

High-density lipoprotein (HDL) particle subpopulations in heterozygous cholesteryl ester transfer protein (CETP) deficiency: maintenance of antioxidative activity

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12 December 2020

Increased oxidized low-density lipoprotein causes blood-brain barrier disruption in early-onset preeclampsia through LOX-1

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12 December 2020

Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells

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12 December 2020

Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis

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12 December 2020

Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib

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12 December 2020

Effect of plasma lipids and APOE genotype on cognitive decline

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12 December 2020

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

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12 December 2020

A model of lysosomal pH regulation

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12 December 2020

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

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12 December 2020

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

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12 December 2020

What are lipoproteins doing in the brain?

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12 December 2020

Associations between serum cholesterol levels and cerebral amyloidosis

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12 December 2020

Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP

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12 December 2020

The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPase

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12 December 2020

Possible role of vascular risk factors in Alzheimer's disease and vascular dementia

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12 December 2020

Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain.

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12 December 2020

The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid

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12 December 2020

Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain.

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12 December 2020

Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

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12 December 2020

Blood-brain barrier breakdown in the aging human hippocampus

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12 December 2020

BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release

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12 December 2020

Cerebral microbleeds as a biomarker in Alzheimer's disease? A review in the field

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12 December 2020

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

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12 December 2020

Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases

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12 December 2020

Cerebral microbleeds topography and cerebrospinal fluid biomarkers in cognitive impairment

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12 December 2020

Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery

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12 December 2020

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

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12 December 2020

Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification

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12 December 2020

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.

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12 December 2020

Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging.

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12 December 2020

BK channel agonist represents a potential therapeutic approach for lysosomal storage diseases

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12 December 2020

Cathepsin D as a therapeutic target in Alzheimer's disease.

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12 December 2020

The blood brain barrier in Alzheimer's disease.

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12 December 2020

Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage.

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12 December 2020

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

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12 December 2020

Subtle blood-brain barrier leakage rate and spatial extent: Considerations for dynamic contrast-enhanced MRI.

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12 December 2020

Comparative Analysis of Cortical Microinfarcts and Microbleeds using 3.0-Tesla Postmortem Magnetic Resonance Images and Histopathology

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12 December 2020

Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells

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12 December 2020

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro and in vivo characterization.

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12 December 2020