The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake (Q64271803)

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English	The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake	No description defined

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scholarly article

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title

The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake (English)

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main subject

SUMOylation

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proteostasis

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author name string

Etienne Cartier

series ordinal

1

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Jennie Garcia-Olivares

series ordinal

2

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Eric Janezic

series ordinal

3

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Juan Viana

series ordinal

4

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Michael Moore

series ordinal

5

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Min Landon Lin

series ordinal

6

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Jeffrey L Caplan

series ordinal

7

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Gonzalo Torres

series ordinal

8

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Yong-Hwan Kim

series ordinal

9

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language of work or name

English

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publication date

2019

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published in

Frontiers in Cellular Neuroscience

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volume

13

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page(s)

35

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copyright license

Creative Commons Attribution 4.0 International

start time

8 February 2019

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stated in

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

stated in

Europe PubMed Central

retrieved

11 June 2022

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6386010/fullTextXML

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inferred from PubMed Central ID database lookup

cites work

Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity

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Characterization and transplantation of two neuronal cell lines with dopaminergic properties

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Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortalized dopamine cells

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SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

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PubMed

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Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type

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reference URL

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12 December 2020

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Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters

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PubMed

reference URL

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12 December 2020

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The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

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inferred from PubMed ID database lookup

Ubc9 is essential for viability of higher eukaryotic cells

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PubMed

reference URL

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12 December 2020

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inferred from PubMed ID database lookup

Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laser.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

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The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines.

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Oligomerization of Dopamine Transporters Visualized in Living Cells by Fluorescence Resonance Energy Transfer Microscopy

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity.

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of N-glycosylation in function and surface trafficking of the human dopamine transporter

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMO modification of Huntingtin and Huntington's disease pathology

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions.

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive and protein kinase C-induced internalization of the dopamine transporter is mediated by a clathrin-dependent mechanism.

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

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inferred from PubMed ID database lookup

SUMO: a history of modification

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sumoylation silences the plasma membrane leak K+ channel K2P1.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C.

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pias1 interaction and sumoylation of metabotropic glutamate receptor 8

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Cerulean, Venus, and VenusY67C FRET reference standards

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMO on the road to neurodegeneration

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMOylation regulates kainate-receptor-mediated synaptic transmission

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SUMO conjugating enzyme Ubc9 is a regulator of GLUT4 turnover and targeting to the insulin-responsive storage compartment in 3T3-L1 adipocytes

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

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inferred from PubMed ID database lookup

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

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inferred from PubMed ID database lookup

Detecting protein-protein interactions with CFP-YFP FRET by acceptor photobleaching

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Trafficking of dopamine transporters in psychostimulant actions

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitoylation controls dopamine transporter kinetics, degradation, and protein kinase C-dependent regulation

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative proteomic analysis identifies a role for SUMO in protein quality control

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sumoylation inhibits alpha-synuclein aggregation and toxicity.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sumoylation: a regulatory protein modification in health and disease

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMO and Parkinson's disease

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin pathways in neurodegenerative disease

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

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The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

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inferred from PubMed ID database lookup

Brain Region-Specific Trafficking of the Dopamine Transporter

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-dependent and independent roles of SUMO in proteostasis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sumo Modification of Ion Channels.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30828290

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

based on heuristic

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Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30828290

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12 December 2020

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Identifiers

DOI

10.3389/FNCEL.2019.00035

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PMC publication ID

6386010

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PubMed publication ID

30828290

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