Altered force generation and cell-to-cell contractile imbalance in hypertrophic cardiomyopathy (Q64232849)

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22 April 2020

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18 October 2022

Altered force generation and cell-to-cell contractile imbalance in hypertrophic cardiomyopathy (English)

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hypertrophic cardiomyopathy

22 April 2020

main subject

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22 April 2020

Theresia Kraft

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22 April 2020

language of work or name

English

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publication date

11 February 2019

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22 April 2020

1 May 2019

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18 October 2022

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22 April 2020

18 October 2022

471

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22 April 2020

issue

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22 April 2020

page(s)

719-733

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Creative Commons Attribution 4.0 International

22 April 2020

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Energetics and mechanism of actomyosin adenosine triphosphatase

18 October 2022

cites work

1 reference

12 December 2020

Mechanism of the actomyosin adenosine triphosphatase. Evidence that adenosine 5'-triphosphate hydrolysis can occur without dissociation of the actomyosin complex

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12 December 2020

Quantitative analysis of cardiac muscle cell disorganization in the ventricular septum of patients with hypertrophic cardiomyopathy

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12 December 2020

X-ray studies of order-disorder transitions in the myosin heads of skinned rabbit psoas muscles

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12 December 2020

Rapid dissociation and reassociation of actomyosin cross-bridges during force generation: a newly observed facet of cross-bridge action in muscle

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12 December 2020

Parallel inhibition of active force and relaxed fiber stiffness in skeletal muscle by caldesmon: implications for the pathway to force generation

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12 December 2020

Regulation of actomyosin ATPase activity by troponin-tropomyosin: effect of the binding of the myosin subfragment 1 (S-1).ATP complex

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12 December 2020

Structural changes accompanying phosphorylation of tarantula muscle myosin filaments

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Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction

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12 December 2020

Structural changes that occur in scallop myosin filaments upon activation

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12 December 2020

Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis. A study of operatively excised left ventricular outflow tract muscle in 14 patients.

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12 December 2020

The low-angle X-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigor

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12 December 2020

Interaction of Myosin with Thin Filaments during Contraction and Relaxation: Effect of Ionic Strength

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12 December 2020

Myosin isoenzymes in normal and hypertrophied human ventricular myocardium

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12 December 2020

Mechanism of action of troponin . tropomyosin. Inhibition of actomyosin ATPase activity without inhibition of myosin binding to actin

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12 December 2020

X-ray diffraction evidence for cross-bridge formation in relaxed muscle fibers at various ionic strengths

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12 December 2020

The current status of myocardial disarray in hypertrophic cardiomyopathy

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12 December 2020

Crosslinked myosin subfragment 1: a stable analogue of the subfragment-1.ATP complex

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12 December 2020

Small-angle X-ray scattering from myosin heads in relaxed and rigor frog skeletal muscles

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12 December 2020

Evidence for cross-bridge attachment in relaxed muscle at low ionic strength

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12 December 2020

X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-

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12 December 2020

Steric-blocking by Tropomyosin Visualized in Relaxed Vertebrate Muscle Thin Filaments

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12 December 2020

Parallel inhibition of active force and relaxed fiber stiffness by caldesmon fragments at physiological ionic strength and temperature conditions: additional evidence that weak cross-bridge binding to actin is an essential intermediate for force gen

1 reference

12 December 2020

Possible gene dose effect of a mutant cardiac beta-myosin heavy chain gene on the clinical expression of familial hypertrophic cardiomyopathy

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12 December 2020

Three-dimensional structure of myosin subfragment-1: a molecular motor

1 reference

12 December 2020

X-ray structure of the magnesium(II).ADP.vanadate complex of the Dictyostelium discoideum myosin motor domain to 1.9 A resolution

1 reference

12 December 2020

Myosin light chain phosphorylation affects the structure of rabbit skeletal muscle thick filaments

1 reference

12 December 2020

Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy

1 reference

12 December 2020

Novel splice donor site mutation in the cardiac myosin-binding protein-C gene in familial hypertrophic cardiomyopathy. Characterization Of cardiac transcript and protein

1 reference

12 December 2020

X-ray diffraction studies of cross-bridges weakly bound to actin in relaxed skinned fibers of rabbit psoas muscle

1 reference

12 December 2020

Temperature-induced structural changes in the myosin thick filament of skinned rabbit psoas muscle

1 reference

12 December 2020

Familial hypertrophic cardiomyopathy: from mutations to functional defects

1 reference

12 December 2020

A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy

1 reference

12 December 2020

The effect of thin filament activation on the attachment of weak binding cross-bridges: A two-dimensional x-ray diffraction study on single muscle fibers

1 reference

12 December 2020

Variability in the ratio of mutant to wildtype myosin heavy chain present in the soleus muscle of patients with familial hypertrophic cardiomyopathy. A new approach for the quantification of mutant to wildtype protein

1 reference

12 December 2020

Structural mechanism of muscle contraction.

1 reference

12 December 2020

Homozygotes for a R869G Mutation in the β -myosin Heavy Chain Gene have a Severe Form of Familial Hypertrophic Cardiomyopathy

1 reference

12 December 2020

Cyclic stretch induces the release of growth promoting factors from cultured neonatal cardiomyocytes and cardiac fibroblasts

1 reference

12 December 2020

Three-dimensional image reconstruction of dephosphorylated smooth muscle heavy meromyosin reveals asymmetry in the interaction between myosin heads and placement of subfragment 2

1 reference

12 December 2020

The role of angiotensin II, endothelin-1 and transforming growth factor-beta as autocrine/paracrine mediators of stretch-induced cardiomyocyte hypertrophy.

1 reference

12 December 2020

The myosin swinging cross-bridge model.

1 reference

12 December 2020

Multiple structures of thick filaments in resting cardiac muscle and their influence on cross-bridge interactions

1 reference

12 December 2020

Relation between myocyte disarray and outcome in hypertrophic cardiomyopathy

1 reference

12 December 2020

Hypertrophic cardiomyopathy: a systematic review

1 reference

12 December 2020

Mutation of the myosin converter domain alters cross-bridge elasticity

1 reference

12 December 2020

Stochastic gene expression in a single cell

1 reference

12 December 2020

Stretch-induced paracrine hypertrophic stimuli increase TGF-beta1 expression in cardiomyocytes

1 reference

12 December 2020

Temperature and ligand dependence of conformation and helical order in myosin filaments

1 reference

12 December 2020

Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy

1 reference

12 December 2020

Different functional properties of troponin T mutants that cause dilated cardiomyopathy

1 reference

12 December 2020

Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy

1 reference

12 December 2020

Electron microscope studies of the organisation of the filaments in striated muscle

1 reference

12 December 2020

Structural changes in muscle during contraction; interference microscopy of living muscle fibres

1 reference

12 December 2020

Changes in the cross-striations of muscle during contraction and stretch and their structural interpretation

1 reference

12 December 2020

Muscle structure and theories of contraction

1 reference

12 December 2020

Cardiac myosin binding protein C: its role in physiology and disease

1 reference

12 December 2020

Hypertrophic cardiomyopathy

1 reference

12 December 2020

Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy

1 reference

12 December 2020

Hypertrophic cardiomyopathy-related beta-myosin mutations cause highly variable calcium sensitivity with functional imbalances among individual muscle cells

1 reference

12 December 2020

Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype

1 reference

12 December 2020

Atomic model of a myosin filament in the relaxed state

1 reference

12 December 2020

X-ray diffraction studies of the thick filament in permeabilized myocardium from rabbit

1 reference

12 December 2020

Stochastic mRNA synthesis in mammalian cells

1 reference

12 December 2020

The structure of isolated cardiac Myosin thick filaments from cardiac Myosin binding protein-C knockout mice

1 reference

12 December 2020

Quantification of mutant versus wild-type myosin in human muscle biopsies using nano-LC/ESI-MS

1 reference

12 December 2020

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

1 reference

12 December 2020

Head-head and head-tail interaction: a general mechanism for switching off myosin II activity in cells

1 reference

12 December 2020

Nature, nurture, or chance: stochastic gene expression and its consequences

1 reference

12 December 2020

Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction

1 reference

12 December 2020

Stabilization of helical order in the thick filaments by blebbistatin: further evidence of coexisting multiple conformations of myosin

1 reference

12 December 2020

Expression patterns of cardiac myofilament proteins: genomic and protein analysis of surgical myectomy tissue from patients with obstructive hypertrophic cardiomyopathy.

1 reference

12 December 2020

Cardiomyopathy: a systematic review of disease-causing mutations in myosin heavy chain 7 and their phenotypic manifestations

1 reference

12 December 2020

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

1 reference

12 December 2020

Prevalence of sarcomere protein gene mutations in preadolescent children with hypertrophic cardiomyopathy

1 reference

12 December 2020

Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development.

1 reference

12 December 2020

Allele-specific differences in ryanodine receptor 1 mRNA expression levels may contribute to phenotypic variability in malignant hyperthermia

1 reference

12 December 2020

Prevalence and spectrum of mutations in a cohort of 192 unrelated patients with hypertrophic cardiomyopathy

1 reference

12 December 2020

Single-allele analysis of transcription kinetics in living mammalian cells

1 reference

12 December 2020

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.

1 reference

12 December 2020

Cardiac myosin-binding protein C in hypertrophic cardiomyopathy: Mechanisms and therapeutic opportunities

1 reference

12 December 2020

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

1 reference

12 December 2020

Disease Pathways and Novel Therapeutic Targets in Hypertrophic Cardiomyopathy

1 reference

12 December 2020

Unequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy.

1 reference

12 December 2020

Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function

1 reference

12 December 2020

Variants in the 3' untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner

1 reference

12 December 2020

Cardiac and skeletal muscle expression of mutant β-myosin heavy chains, degree of functional impairment and phenotypic heterogeneity in hypertrophic cardiomyopathy

1 reference

12 December 2020

Genetics of hypertrophic cardiomyopathy after 20 years: clinical perspectives

1 reference

12 December 2020

Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor

1 reference

12 December 2020

Hypertrophic cardiomyopathy

1 reference

12 December 2020

Transcriptional burst frequency and burst size are equally modulated across the human genome

1 reference

12 December 2020

Atomic model of the human cardiac muscle myosin filament.

1 reference

12 December 2020

Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes

1 reference

12 December 2020

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

1 reference

12 December 2020

Visualizing SNVs to quantify allele-specific expression in single cells

1 reference

12 December 2020

Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy

1 reference

12 December 2020

The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin

1 reference

12 December 2020

Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells

1 reference

12 December 2020

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation

1 reference

12 December 2020

Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy

1 reference

12 December 2020

Structural implications of β-cardiac myosin heavy chain mutations in human disease

1 reference

12 December 2020

Familial hypertrophic cardiomyopathy: functional variance among individual cardiomyocytes as a trigger of FHC-phenotype development

1 reference

12 December 2020

Diltiazem treatment for pre-clinical hypertrophic cardiomyopathy sarcomere mutation carriers: a pilot randomized trial to modify disease expression

1 reference

12 December 2020

Biased allelic expression in human primary fibroblast single cells

1 reference

12 December 2020

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

1 reference

12 December 2020

Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology

1 reference

12 December 2020

New perspectives on the prevalence of hypertrophic cardiomyopathy

1 reference

12 December 2020

Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments.

1 reference

12 December 2020

The Ups and Downs of Genetic Diagnosis of Hypertrophic Cardiomyopathy

1 reference

12 December 2020

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

1 reference

12 December 2020

Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments

1 reference

12 December 2020

Spectrum of Mutations in Hypertrophic Cardiomyopathy Genes Among Tunisian Patients

1 reference

12 December 2020

How Myosin Generates Force on Actin Filaments

1 reference

12 December 2020

Hypertrophic Cardiomyopathy: Cell-to-Cell Imbalance in Gene Expression and Contraction Force as Trigger for Disease Phenotype Development

1 reference

12 December 2020

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes.

1 reference

12 December 2020

Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments

1 reference

12 December 2020

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

1 reference

12 December 2020

Myosin filament activation in the heart is tuned to the mechanical task.

1 reference

12 December 2020

SCALE: modeling allele-specific gene expression by single-cell RNA sequencing.

1 reference

12 December 2020

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

1 reference

12 December 2020

The role of super-relaxed myosin in skeletal and cardiac muscle

1 reference

12 December 2020

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.

1 reference

12 December 2020

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy.

1 reference

12 December 2020

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light

1 reference

12 December 2020

Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy

1 reference

12 December 2020

Intrinsic MYH7 expression regulation contributes to tissue level allelic imbalance in hypertrophic cardiomyopathy

1 reference

12 December 2020

Allelic Expression Imbalance Promoting a Mutant PEX6 Allele Causes Zellweger Spectrum Disorder.

1 reference

12 December 2020

Regulation of Contraction by the Thick Filaments in Skeletal Muscle

1 reference

12 December 2020

Localization of transcripts, translation, and degradation for spatiotemporal sarcomere maintenance.

1 reference

12 December 2020

Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy.

1 reference

12 December 2020

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy

1 reference

12 December 2020

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin.

1 reference

12 December 2020

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

1 reference

12 December 2020

Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy.

1 reference

12 December 2020

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

1 reference

12 December 2020

Allelic imbalance and haploinsufficiency in MYBPC3-linked hypertrophic cardiomyopathy

1 reference

12 December 2020

10.1007/S00424-019-02260-9

Identifiers

DOI

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22 April 2020

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22 April 2020

PubMed publication ID

30740621

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