Unleashing the Synthetic Power of Plant Oxygenases: From Mechanism to Application (Q64231565)

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20 April 2020

title

Unleashing the Synthetic Power of Plant Oxygenases: From Mechanism to Application (English)

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20 April 2020

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20 April 2020

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20 April 2020

author name string

Andrew J Mitchell

series ordinal

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Jing-Ke Weng

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language of work or name

English

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publication date

22 January 2019

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20 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30670605%20AND%20SRC:MED&resulttype=core&format=json

20 April 2020

volume

179

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20 April 2020

issue

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20 April 2020

page(s)

813-829

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Biosynthesis of Stizolobinic Acid and Stizolobic Acid in Higher Plants. An Enzyme System(s) Catalyzing the Conversion of Dihydroxyphenylalanine into Stizolobinic Acid and Stizolobic Acid from Etiolated Seedlings of Stizolobium hassjoo

20 April 2020

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Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria.

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Evidence for basic ferryls in cytochromes P450.

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Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

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An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor

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Structural Insights into Maize Viviparous14, a Key Enzyme in the Biosynthesis of the Phytohormone Abscisic Acid

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Unusual P450 reactions in plant secondary metabolism.

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12 December 2020

The main auxin biosynthesis pathway in Arabidopsis

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12 December 2020

The Arabidopsis YUCCA1 flavin monooxygenase functions in the indole-3-pyruvic acid branch of auxin biosynthesis

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Making sense of low oxygen sensing

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Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

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Enhanced tolerance and remediation to mixed contaminates of PCBs and 2,4-DCP by transgenic alfalfa plants expressing the 2,3-dihydroxybiphenyl-1,2-dioxygenase

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The re-emergence of natural products for drug discovery in the genomics era.

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Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution

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Genome-guided investigation of plant natural product biosynthesis

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Analysis of phylogenetic and functional diverge in plant nine-cis epoxycarotenoid dioxygenase gene family

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Structural Insights into Substrate Specificity of Feruloyl-CoA 6'-Hydroxylase from Arabidopsis thaliana

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The Origin and Evolution of Baeyer-Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases.

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Applications of Fluorine in Medicinal Chemistry

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Identification of a flavin-containing S-oxygenating monooxygenase involved in alliin biosynthesis in garlic

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Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.

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Engineering of Secondary Metabolism

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Synthetic biology to access and expand nature's chemical diversity

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CYP96T1 of Narcissus sp. aff. pseudonarcissus Catalyzes Formation of the Para-Para' C-C Phenol Couple in the Amaryllidaceae Alkaloids

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Transfer of the cytochrome P450-dependent dhurrin pathway from Sorghum bicolor into Nicotiana tabacum chloroplasts for light-driven synthesis

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Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity

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A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

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Structure-Guided Reprogramming of a Hydroxylase To Halogenate Its Small Molecule Substrate.

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A 2-Oxoglutarate-Dependent Dioxygenase Mediates the Biosynthesis of Glucoraphasatin in Radish.

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Assembly of Dynamic P450-Mediated Metabolons-Order Versus Chaos

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Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

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Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate.

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Ethylene Role in Plant Growth, Development and Senescence: Interaction with Other Phytohormones

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The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions

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Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions

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Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme.

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Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist.

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Baeyer-Villiger Monooxygenase FMO5 as Entry Point in Drug Metabolism

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Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase

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Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes.

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Directed Evolution: Bringing New Chemistry to Life

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Applications of Oxygenases in the Chemoenzymatic Total Synthesis of Complex Natural Products

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Dioxygen Activation by Nonheme Diiron Enzymes: Diverse Dioxygen Adducts, High-Valent Intermediates, and Related Model Complexes

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Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway.

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Total Synthesis of Tambromycin by Combining Chemocatalytic and Biocatalytic C-H Functionalization.

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Expanding the roles for 2-oxoglutarate-dependent oxygenases in plant metabolism.

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Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions.

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Diiron monooxygenases in natural product biosynthesis.

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Biocatalytic oxidation reactions - a Chemist's perspective.

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Flavin Monooxygenase-Generated N-Hydroxypipecolic Acid Is a Critical Element of Plant Systemic Immunity

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Enzymatic construction of highly strained carbocycles

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Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance

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Halogenase engineering and its utility in medicinal chemistry

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Evolution of Biocatalytic and Chemocatalytic C-H Functionalization Strategy in the Synthesis of Manzacidin C

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The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors

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Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions

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12 December 2020

Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase

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12 December 2020

Improving catalytic activity of the Baeyer-Villiger monooxygenase-based Escherichia coli biocatalysts for the overproduction of (Z)-11-(heptanoyloxy)undec-9-enoic acid from ricinoleic acid.

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12 December 2020

Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases

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12 December 2020

Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution

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12 December 2020