Regulation of BRCA1 expression by the Rb-E2F pathway. (Q53413911)

14 May 2018

title

Regulation of BRCA1 expression by the Rb-E2F pathway. (English)

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14 May 2018

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author name string

Wang A

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Schneider-Broussard R

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Kumar AP

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MacLeod MC

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language of work or name

English

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publication date

1 February 2000

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Journal of Biological Chemistry

published in

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volume

275

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issue

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page(s)

4532-4536

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The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

cites work

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Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice

21 January 2018

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Identification of a RING protein that can interact in vivo with the BRCA1 gene product

21 January 2018

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Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

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Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

21 January 2018

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BRCA1 is a component of the RNA polymerase II holoenzyme

21 January 2018

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Evidence for a transcriptional activation function of BRCA1 C-terminal region

21 January 2018

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BRCA1 physically associates with p53 and stimulates its transcriptional activity.

21 January 2018

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BRCA1 regulates p53-dependent gene expression

21 January 2018

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Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

21 January 2018

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21 January 2018

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Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

21 January 2018

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Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

21 January 2018

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Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts

21 January 2018

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pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

21 January 2018

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

21 January 2018

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p53 and E2F-1 cooperate to mediate apoptosis

21 January 2018

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Distinct roles for E2F proteins in cell growth control and apoptosis

21 January 2018

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E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

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Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

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p14ARF links the tumour suppressors RB and p53.

21 January 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

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E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model

21 January 2018

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Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells

21 January 2018

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Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression

21 January 2018

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Isolation of the murine Nbr1 gene adjacent to the murine Brca1 gene

21 January 2018

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Subunit Composition Determines E2F DNA-Binding Site Specificity

21 January 2018

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Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter

21 January 2018

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Mechanism of active transcriptional repression by the retinoblastoma protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.6.4532

Complex regulation of the BRCA1 gene.

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https://api.crossref.org/works/10.1074%2FJBC.275.6.4532

Retinoblastoma protein switches the E2F site from positive to negative element

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A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites

21 January 2018

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The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

21 January 2018

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The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif

21 January 2018

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E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.6.4532

BRCA1-associated growth arrest is RB-dependent

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.6.4532

The transcription factor E2F-1 mediates the autoregulation of RB gene expression

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.6.4532

Rapid analysis of gene expression (RAGE) facilitates universal expression profiling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.6.4532

Transcriptional activation by BRCA1

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https://api.crossref.org/works/10.1074%2FJBC.275.6.4532

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.6.4532

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

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https://api.crossref.org/works/10.1074%2FJBC.275.6.4532

21 January 2018

Identifiers

DOI

10.1074/JBC.275.6.4532

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14 May 2018

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14 May 2018