Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. (Q52041047)

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scientific article published on 24 August 2005

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English	Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.	scientific article published on 24 August 2005

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scholarly article

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Europe PubMed Central

PubMed publication ID

16120640

retrieved

20 April 2018

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http://europepmc.org/abstract/MED/16120640

title

Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning (English)

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Europe PubMed Central

PMC publication ID

6986394

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retrieved

14 May 2020

author

Mark Lewandoski

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2

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PMC publication ID

6986394

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14 May 2020

author name string

Jamie M Verheyden

series ordinal

1

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Europe PubMed Central

PMC publication ID

6986394

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

retrieved

14 May 2020

Chuxia Deng

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3

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PMC publication ID

6986394

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

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14 May 2020

Brian D Harfe

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4

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Europe PubMed Central

PMC publication ID

6986394

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14 May 2020

Xin Sun

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5

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Europe PubMed Central

PMC publication ID

6986394

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

retrieved

14 May 2020

language of work or name

English

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publication date

24 August 2005

1 reference

stated in

Europe PubMed Central

PubMed publication ID

16120640

retrieved

20 April 2018

reference URL

http://europepmc.org/abstract/MED/16120640

number of pages

11

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published in

Development

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stated in

Europe PubMed Central

PMC publication ID

6986394

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

retrieved

14 May 2020

volume

132

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Europe PubMed Central

PMC publication ID

6986394

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

retrieved

14 May 2020

issue

19

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Europe PubMed Central

PMC publication ID

6986394

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

retrieved

14 May 2020

page(s)

4235-4245

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Europe PubMed Central

PMC publication ID

6986394

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

retrieved

14 May 2020

cites work

Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

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Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

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Regulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implications

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell death in the "opaque patch" in the central mesenchyme of the developing chick limb: a cytological, cytochemical and electron microscopic analysis

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A positive feedback loop coordinates growth and patterning in the vertebrate limb.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of FGF signalling from the apical ectodermal ridge in limb development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor specificity of the fibroblast growth factor family

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal‐epithelial interactions

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial and temporal patterns of ERK signaling during mouse embryogenesis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental expression of two murine fibroblast growth factor receptors, flg and bek

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of the Fgf and Fgfr gene families

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct regulatory control of the Brachyury gene in axial and non-axial mesoderm suggests separation of mesoderm lineages early in mouse gastrulation.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial and temporal patterns of cell death in limb bud mesoderm after apical ectodermal ridge removal

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FGF-2: apical ectodermal ridge growth signal for chick limb development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine FGFR-1 is required for early postimplantation growth and axial organization

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and morphology in mouse embryos by confocal laser scanning microscopy

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of Fgfr1 conditional knockout mice

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

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Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fgf8 signalling from the AER is essential for normal limb development.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fgf10 is essential for limb and lung formation

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chick oligozeugodactyly (ozd) mutant lacks sonic hedgehog function in the limb

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some distal limb structures develop in mice lacking Sonic hedgehog signaling

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

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Pattern formation: old models out on a limb.

1 reference

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

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Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IIIc alternative of Fgfr2 is a positive regulator of bone formation.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A re-examination of proximodistal patterning during vertebrate limb development

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generalized lacZ expression with the ROSA26 Cre reporter strain

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos

1 reference

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https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the fibroblast growth factor receptor FGFR-1/flg during gastrulation and segmentation in the mouse embryo

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocytosis controls spreading and effective signaling range of Fgf8 protein

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/16120640

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12 December 2020

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Identifiers

DOI

10.1242/DEV.02001

1 reference

stated in

Europe PubMed Central

PMC publication ID

6986394

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

retrieved

14 May 2020

PMC publication ID

6986394

1 reference

stated in

Europe PubMed Central

PMC publication ID

6986394

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

retrieved

14 May 2020

PubMed publication ID

16120640

1 reference

stated in

Europe PubMed Central

PMC publication ID

6986394

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6986394&resulttype=core&format=json

retrieved

14 May 2020

 

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