Mathematical models of protein kinase signal transduction. (Q52039321)

20 April 2018

title

Mathematical models of protein kinase signal transduction. (English)

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20 April 2018

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Reinhart Heinrich

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20 April 2018

Tom Rapoport

series ordinal

object named as

Tom A Rapoport

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20 April 2018

author name string

Benjamin G Neel

series ordinal

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20 April 2018

publication date

1 May 2002

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20 April 2018

published in

Molecular Cell

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20 April 2018

volume

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20 April 2018

issue

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20 April 2018

page(s)

957-970

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20 April 2018

A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model.

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Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells

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Signal transduction: hanging on a scaffold.

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Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability

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Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases

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Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

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Taking enzyme kinetics out of control; putting control into regulation

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Ultrasensitivity in the mitogen-activated protein kinase cascade

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Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

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Signaling to Rho GTPases

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Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

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Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

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Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex†

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Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

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Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

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Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates

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Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

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7 January 2021

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Identifiers

DOI

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20 April 2018

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20 April 2018