Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre. (Q52024998)

20 April 2018

title

Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre. (English)

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20 April 2018

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Tarlinton DM

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20 April 2018

Smith KG

series ordinal

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20 April 2018

publication date

1 September 2000

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20 April 2018

published in

Trends in Immunology

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20 April 2018

volume

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20 April 2018

issue

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20 April 2018

page(s)

436-441

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20 April 2018

VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE

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7 January 2021

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.

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Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice

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bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

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Germinal centers and antibody production in bone marrow

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Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens

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Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.

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FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

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Predicted and inferred waiting times for key mutations in the germinal centre reaction: evidence for stochasticity in selection

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Survival of long-lived plasma cells is independent of antigen.

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Dependence of germinal center B cells on expression of CD21/CD35 for survival.

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B cell differentiation and isotype switching is related to division cycle number

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SHIP recruitment attenuates Fc gamma RIIB-induced B cell apoptosis

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Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence

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Identifiers

DOI

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20 April 2018

release_p7u2cou4dbbjlixqqkyrc77pfq

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/p7u2cou4dbbjlixqqkyrc77pfq

24 November 2022

mapped directly with Wikidata item

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20 April 2018