Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage (Q51431498)

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scientific article published in June 2012

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English	Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage	scientific article published in June 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

0 references

right-sided heart failure

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

Michael S. Roberts

7

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

author name string

Peng Li

1

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

Thomas A Robertson

2

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

Qian Zhang

3

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

Linda M Fletcher

4

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

Darrell H G Crawford

5

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

Michael Weiss

6

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

publication date

1 June 2012

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Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

29

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

6

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

1658-1669

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

The liver in heart failure

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Ischemic hepatitis: clinical presentation and pathogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Hepatic disease and drug pharmacokinetics

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity, and nature of drug

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Quantitative evaluation of altered hepatic spaces and membrane transport in fibrotic rat liver

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans

1 reference

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21 January 2018

Tissue distribution kinetics as determinant of transit time dispersion of drugs in organs: application of a stochastic model to the rat hindlimb

1 reference

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21 January 2018

Drug structure-transport relationships

1 reference

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21 January 2018

Effect of nolomirole on monocrotaline-induced heart failure

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

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An assessment of digital image analysis to measure fibrosis in liver biopsy specimens of patients with chronic hepatitis C.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Quantitative determination of cytochrome P-450 in rat liver homogenate

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Cytoplasmic binding and disposition kinetics of diclofenac in the isolated perfused rat liver

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Monocrotaline promotes transplanted cell engraftment and advances liver repopulation in rats via liver conditioning.

1 reference

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Prediction of postoperative hepatic dysfunction after cardiac surgery in patients with chronic congestive heart failure.

1 reference

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Impaired nitroglycerin biotransformation in patients with chronic heart failure

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

An improved nonlinear model describing the hepatic pharmacokinetics of digoxin: evidence for two functionally different uptake systems and saturable binding

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Computational strategies unravel and trace how liver disease changes hepatic drug disposition

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Physiological pharmacokinetics of solutes in the isolated perfused rat hindlimb: characterization of the physiology with changing perfusate flow, protein content, and temperature using statistical moment analysis

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Dermal and underlying tissue pharmacokinetics of salicylic acid after topical application.

1 reference

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21 January 2018

In vitro and in vivo imaging of xenobiotic transport in human skin and in the rat liver

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21 January 2018

On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics.

1 reference

https://api.crossref.org/works/10.1007%2FS11095-012-0690-Z

21 January 2018

Cellular pharmacokinetics: effects of cytoplasmic diffusion and binding on organ transit time distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

based on heuristic

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Structure-hepatic disposition relationships for cationic drugs in isolated perfused rat livers: transmembrane exchange and cytoplasmic binding process

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Portal vein pulsatility ratio and heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The liver in heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia and drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the validity of the dispersion model of hepatic drug elimination when intravascular transit time densities are long-tailed

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modeling of hepatic elimination and organ distribution kinetics with the extended convection-dispersion model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

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Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

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Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

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inferred from PubMed ID database lookup

Altered prazosin pharmacokinetics in congestive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

12 December 2020

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Impaired elimination of propranolol due to right heart failure: drug clearance in the isolated liver and its relationship to intrinsic metabolic capacity

1 reference

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Right heart failure impairs hepatic oxygenation and theophylline clearance in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22302523

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In silico representation of the liver-connecting function to anatomy, physiology and heterogeneous microenvironments.

1 reference

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Right heart failure impairs hepatic elimination of p-nitrophenol without inducing changes in content or latency of hepatic UDP-glucuronosyltransferases

1 reference

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An Optimized Model for Rat Liver Perfusion Studies

1 reference

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Effects of chronic left ventricular failure on hepatic oxygenation and theophylline elimination in the rat

1 reference

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Identifiers

10.1007/S11095-012-0690-Z

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 April 2018

http://europepmc.org/abstract/MED/22302523

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