Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens (Q50878605)

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scientific article published on 22 June 2013

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English	Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens	scientific article published on 22 June 2013

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scholarly article

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

Deciphering and engineering of the final step halogenase for improved chlortetracycline biosynthesis in industrial Streptomyces aureofaciens (English)

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

Streptomyces aureofaciens

object named as

Streptomyces aureofaciens

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based on heuristic

inferred from title

4

object named as

Zixin Deng

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

author name string

Tao Zhu

1

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

Xueqing Cheng

2

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

Yuntian Liu

3

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

Delin You

5

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

publication date

22 June 2013

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

Metabolic Engineering

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

19

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

69-78

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

Molecular mechanisms of antibacterial multidrug resistance

1 reference

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Variation in Streptomyces aureofaciens

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The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins

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The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit

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A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics

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Synthesis of 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) via 9-nitro-6-demethyl-6-deoxytetracycline

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Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline

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Tigecycline: a glycylcycline antimicrobial agent

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Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination

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Structural basis for TetM-mediated tetracycline resistance

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Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis

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Aureomycin; a product of the continuing search for new antibiotics

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Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.

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What's new in enzymatic halogenations

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Novel chemobiosynthetic approach for exclusive production of FK506.

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Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis

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High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain.

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Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

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7 January 2021

5-Hydroxy-7-chlortetracycline

1 reference

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7 January 2021

Identification and cloning of the gene involved in the final step of chlortetracycline biosynthesis in Streptomyces aureofaciens.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2013.06.003

7 January 2021

Mechanism of the incidental production of a melanin-like pigment during 6-demethylchlortetracycline production in Streptomyces aureofaciens.

1 reference

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7 January 2021

Halogenation strategies in natural product biosynthesis

1 reference

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7 January 2021

Phosphomannose isomerase and phosphomannomutase gene disruptions in Streptomyces nodosus: impact on amphotericin biosynthesis and implications for glycosylation engineering.

1 reference

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7 January 2021

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

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Genetics of Streptomyces rimosus, the oxytetracycline producer.

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7 January 2021

Decoding and engineering tetracycline biosynthesis

1 reference

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7 January 2021

Oxytetracycline biosynthesis

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7 January 2021

Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

1 reference

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7 January 2021

A robust platform for the synthesis of new tetracycline antibiotics

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7 January 2021

Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway.

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7 January 2021

The tetracycline resistome

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DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway

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7 January 2021

Nature's inventory of halogenation catalysts: oxidative strategies predominate

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7 January 2021

How many genes are required for the synthesis of chlortetracycline?

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7 January 2021

The biosynthesis of tetracycline

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Heterologous expression and manipulation of three tetracycline biosynthetic pathways.

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Application of a double-reporter-guided mutant selection method to improve clavulanic acid production in Streptomyces clavuligerus.

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Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH.

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Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis

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Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes

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Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase

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Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.

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Cloning and characterization of the pyrrolomycin biosynthetic gene clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. strain UC 11065

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Biosynthesis of tetracycline by 5-hydroxy-tetracycline-producing cultures of Streptomyces rimosus

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10.1016/J.YMBEN.2013.06.003

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Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 March 2018

http://europepmc.org/abstract/MED/23800859

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