Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation (Q50641169)

17 March 2018

title

Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation (English)

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17 March 2018

author name string

Takahiro M Ishii

series ordinal

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17 March 2018

Noriyuki Nakashima

series ordinal

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17 March 2018

Harunori Ohmori

series ordinal

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17 March 2018

language of work or name

English

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publication date

21 December 2006

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17 March 2018

published in

Journal of Physiology

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17 March 2018

volume

579

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17 March 2018

issue

Pt 2

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17 March 2018

page(s)

291-301

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17 March 2018

Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels

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The S4-S5 linker couples voltage sensing and activation of pacemaker channels.

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Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype

21 January 2018

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21 January 2018

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21 January 2018

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Two pacemaker channels from human heart with profoundly different activation kinetics

21 January 2018

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Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages.

21 January 2018

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Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties

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Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents

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Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain

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Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis

21 January 2018

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Features of MotA proton channel structure revealed by tryptophan-scanning mutagenesis

21 January 2018

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Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate

21 January 2018

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Structural basis of two-stage voltage-dependent activation in K+ channels

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Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed

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Kinetic and ionic properties of the human HCN2 pacemaker channel

25 August 2018

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Short antisense oligonucleotide-mediated inhibition is strongly dependent on oligo length and concentration but almost independent of location of the target sequence.

25 August 2018

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Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain

25 August 2018

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12 December 2020

Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels

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12 December 2020

Inward current activated during hyperpolarization in the rabbit sinoatrial node cell

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12 December 2020

A voltage-clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones

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10.1113/JPHYSIOL.2006.124297

Identifiers

DOI

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17 March 2018

release_rs2uyppkgbggre2nhegljlzuva

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/rs2uyppkgbggre2nhegljlzuva

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2075410

0 references

1 reference

17 March 2018