TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation. (Q50530934)

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9 March 2020

title

TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation (English)

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9 March 2020

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9 March 2020

Nobuyuki Kimura

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9 March 2020

Yuto Watanabe

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9 March 2020

Sumiko Watanabe

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9 March 2020

Akira Ishihama

series ordinal

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9 March 2020

publication date

24 February 2016

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9 March 2020

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volume

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issue

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page(s)

466-481

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Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

9 March 2020

cites work

1 reference

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

Identification of RNA-protein interaction networks using PAR-CLIP

21 January 2018

1 reference

Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS

21 January 2018

1 reference

Characterizing TDP-43 interaction with its RNA targets

21 January 2018

1 reference

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

21 January 2018

1 reference

Dendritic mRNA: transport, translation and function

21 January 2018

1 reference

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

21 January 2018

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Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

21 January 2018

1 reference

Quadruplex DNA: sequence, topology and structure

21 January 2018

1 reference

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

21 January 2018

1 reference

C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes

21 January 2018

1 reference

CGG repeats in RNA modulate expression of TDP-43 in mouse and fly models of fragile X tremor ataxia syndrome

21 January 2018

1 reference

C9orf72 nucleotide repeat structures initiate molecular cascades of disease.

21 January 2018

1 reference

TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.

21 January 2018

1 reference

RNA-binding proteins and translational regulation in axons and growth cones

21 January 2018

1 reference

Therapeutic potential of anti-interleukin-17A aptamer: suppression of interleukin-17A signaling and attenuation of autoimmunity in two mouse models.

21 January 2018

1 reference

Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice

21 January 2018

1 reference

Kinesin transports RNA: isolation and characterization of an RNA-transporting granule

21 January 2018

1 reference

QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences

21 January 2018

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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

21 January 2018

1 reference

An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation

21 January 2018

1 reference

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

21 January 2018

1 reference

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

21 January 2018

1 reference

Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic

21 January 2018

1 reference

Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

21 January 2018

1 reference

RNA-binding proteins in human genetic disease

21 January 2018

1 reference

mRNA localization: gene expression in the spatial dimension

21 January 2018

1 reference

The 3'-untranslated region of CaMKII alpha is a cis-acting signal for the localization and translation of mRNA in dendrites

21 January 2018

1 reference

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

21 January 2018

1 reference

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

21 January 2018

1 reference

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

21 January 2018

1 reference

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

21 January 2018

1 reference

Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter

21 January 2018

1 reference

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

21 January 2018

1 reference

Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule

21 January 2018

1 reference

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

21 January 2018

1 reference

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

21 January 2018

1 reference

TDP-43 dimerizes in human cells in culture.

21 January 2018

1 reference

G-quadruplex RNA structure as a signal for neurite mRNA targeting

21 January 2018

1 reference

Dendritic protein synthesis, synaptic plasticity, and memory

21 January 2018

1 reference

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

21 January 2018

1 reference

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

21 January 2018

1 reference

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

21 January 2018

1 reference

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

21 January 2018

1 reference

G-quadruplex formation by human telomeric repeats-containing RNA in Na+ solution

21 January 2018

1 reference

p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/GTC.12352

1 reference

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9 March 2020

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